SAB3500723

Anti-TM4SF1 antibody produced in rabbit

affinity isolated antibody

• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Poids mol.: 22 kDa
• Espèces réactives: rat, human, mouse
• Concentration: 1 mg/mL
• Technique(s): ELISA: suitable; western blot: suitable
• Numéro d'accès NCBI: NP_055035
• Numéro d'accès UniProt: P30408
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... TM4SF1(4071)

Description

Description générale

Transmembrane 4 L6 family member 1 (TM4SF1) is a protein encoded by the TM4SF1 gene in humans. It is a cell surface antigen, which is highly expressed in lung, breast, colon and ovarian carcinomas. The TM4SF1 gene is localized on human chromosome 3q25.1.

Immunogène

Antibody was raised against an 18 amino acid peptide near the amino terminus of human TM4SF1.

Actions biochimiques/physiologiques

Transmembrane 4 L6 family member 1 (TM4SF1) has a novel function in androgen receptor (AR) signaling. Its mRNA expression is higher in prostate cancer tissues as compared to benign prostatic hyperplasia (BPH). It is found to contribute to prostate cancer cell metastasis. The TM4SF1 gene serves as a molecular organizer that interacts with membrane and cytoskeleton-associated proteins. It uniquely initiates the formation of nanopodia and facilitates cell polarization and migration. TM4SF1 also regulates tumor cell motility and invasiveness. It is abundant on the plasma membrane and on intracellular vesicles.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Liaison

The action of this antibody can be blocked using blocking peptide SBP3500723.

Forme physique

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable