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SAB1307254

Sigma-Aldrich

ANTI-BAT1(C-TERMINAL) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

56 kDa U2AF65-associated protein, BAT1, DDX39B, Spliceosome RNA helicase DDX39B, UAP56

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

48991 Da

Espèces réactives

human

Technique(s)

flow cytometry: 1:10-1:50
immunohistochemistry: 1:10-1:50
western blot: 1:1000

Numéro d'accès NCBI

NP_004631.1

Numéro d'accès UniProt

Q13838

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... DDX39B(7919)

Catégories apparentées

Description générale

BAT1, also known as UAP56 or DExD-box helicase 39B (DDX39B), is encoded in the central region of the major histocompatibility complex (MHC) on the short arm of human chromosome 6p21.33. It is a member of DEAD box family of RNA-binding proteins and is characterized with the nine conserved motifs including ATPase and RNA helicase motifs.

Application

ANTI-BAT1(C-TERMINAL) antibody produced in rabbit has been used in immunoprecipitation and western blotting.

Actions biochimiques/physiologiques

BAT1/ UAP56 facilitates the binding of U2 small nuclear ribonucleoprotein (SnRP) to pre-mRNA. It also helps in the export of mRNA from the nucleus to the cytoplasm. Spliceosome RNA helicase BAT1 is implicated in adapting nucleic acid metabolism to cellular stress. BAT1 is implicated in the down-regulation of inflammation. The gene polymorphism might be associated with the development of allergic diseases such as bronchial asthma, allergic rhinitis, atopic dermatitis, food allergy, drug allergy and pollen allergy. Mutation in the gene may also lead to the development of urticaria and Quincke′s edema.

Forme physique

Supplied in PBS with 0.09% (W/V) sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Influenza Virus mRNA Trafficking Through Host Nuclear Speckles.
Mor A, et al.
Nature microbiology, 2016 (2016)
M B Freĭdin et al.
Molekuliarnaia biologiia, 45(3), 464-472 (2011-07-28)
Genome-wide association studies are currently considered as one of the most powerful tools to establishing the genetic basis of complex diseases. A number of such studies were carried out for allergic diseases; however, in Russian population this analysis has not
Hang Shi et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(51), 17628-17633 (2004-12-09)
Pre-mRNA splicing requires the function of a number of RNA-dependent ATPases/helicases, yet no three-dimensional structure of any spliceosomal ATPases/helicases is known. The highly conserved DECD-box protein UAP56/Sub2 is an essential splicing factor that is also important for mRNA export. The
Amir Mor et al.
Nature microbiology, 1(7), 16069-16069 (2016-08-31)
Influenza A virus is a human pathogen with a genome composed of eight viral RNA segments that replicate in the nucleus. Two viral mRNAs are alternatively spliced. The unspliced M1 mRNA is translated into the matrix M1 protein, while the
EunMi Juliana Jung et al.
Proteomics, 7(21), 3906-3918 (2007-10-09)
Ambient particulate matter (PM) induces adverse health effects through the ability of pro-oxidative chemicals to induce the production of oxygen radicals and oxidant injury. Utilizing a proteomics strategy involving 2-D DIGE, immunoblotting, and real-time PCR, we demonstrate that organic diesel
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