SAB1306388

ANTI-ACTIVIN RECEPTOR TYPE IA (ACVR1) (CENTER R147) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonyme(s) : ACVR1, ACVRLK2, Activin receptor type I, Activin receptor type-1, Activin receptor-like kinase 2
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: IgG fraction of antiserum
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: 57153 Da
• Espèces réactives: human, mouse
• Technique(s): immunohistochemistry: 1:50-1:100; western blot: 1:1000
• Numéro d'accès NCBI: NP_001096.1
• Numéro d'accès UniProt: Q04771
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... ACVR1(90)

Description

Description générale

Activin A receptor type 1 (ACVR1) gene encodes a transmembrane protein that belongs to the bone morphogenetic protein (BMP) type I receptors subfamily of the transforming growth factor-β (TGF-β) receptors. ACVR1 is a single-pass type I membrane protein with a ligand-binding extracellular domain, a transmembrane domain, and a cytoplasmic domain. ACVR1 gene is expressed abundantly in endothelial cells, parenchymal cells, fibroblasts, and tumor-derived epithelial cells. This gene is located on human chromosome 2q24.1.

Application

Anti-Activin receptor type IA (ACVR1) (CENTER R147) antibody produced in rabbit has been used in immunohistochemistry (1:100) and western blot (1:100).

Actions biochimiques/physiologiques

Activin A receptor type 1 (ACVR1) protein can bind activin in concert with activin receptor type 2 (ActRII) or activin receptor type-2B (ActRIIB). It participates in activin signaling. It is also capable of forming a complex with either the bone morphogenetic protein (BMP)-2/7-bound bone morphogenetic protein receptor type II (BMPR-II) or activin A receptor type 2A/2B (ACVR2A/ACVR2B). Somatic mutations of the ACVR1 gene are associated with primary ovary and colon cancer. It is considered a target gene to fibrodysplasia ossificans progressiva (FOP).

Forme physique

Supplied in PBS with 0.09% (W/V) sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable