S0278

(±)-Sotalol hydrochloride

≥98% (TLC), powder, β-Adrenoceptor antagonist

• Synonyme(s) : N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride
• Formule empirique (notation de Hill): C₁₂H₂₀N₂O₃S · HCl
• Numéro CAS: 959-24-0
• Poids moléculaire : 308.82
• Numéro CE : 213-496-0
• Numéro MDL: MFCD00242937
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278689
• Nomenclature NACRES : NA.77

Propriétés

• product name: (±)-Sotalol hydrochloride, ≥98% (TLC), powder
• Niveau de qualité: 200
• Pureté: ≥98% (TLC)
• Forme: powder
• Couleur: white to off-white
• Solubilité: H₂O: 20 mg/mL
• Auteur: Bayer
• Chaîne SMILES: Cl.CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1
• InChI: 1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
• Clé InChI: VIDRYROWYFWGSY-UHFFFAOYSA-N
• Informations sur le gène: human ... ADRB1(153) , ADRB2(154) , ADRB3(155) , KCNH2(3757)

Description

Application

(±)-Sotalol hydrochloride has been used to test its effect on the cardiac action potential (AP) in human hearts. It has also been used as an β- blocker to determine its effect on free intracellular calcium (Ca²⁺) release and whole-cell currents in mammalian cancer cells.

Actions biochimiques/physiologiques

Potent β-adrenoceptor antagonist; class III antiarrhythmic; prolongs the action potential and increases the refractory period.

Sotalol has a potential to block non-cardioselective β-adrenergic receptors. It acts as an anti-arrhythmic agent and is used as a therapeutic for equine arrhythmias. In addition, sotalol also has an ability to stop atrial fibrillation recurrence.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves