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P3246

Sigma-Aldrich

Pipamperone dihydrochloride

~99% (HPLC), powder

Synonyme(s) :

1′-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4′-bipiperidine]-4′-carboxamide dihydrochloride, R4050

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About This Item

Formule empirique (notation de Hill):
C21H30N3O2F · 2HCl
Numéro CAS:
2448-68-2
Poids moléculaire :
448.40
Numéro CE :
219-507-5
Numéro MDL:
MFCD00242980
Code UNSPSC :
12352200
ID de substance PubChem :
24724576
Nomenclature NACRES :
NA.77

Pureté

~99% (HPLC)

Niveau de qualité

100

Forme

powder

Couleur

white

Solubilité

H2O: >2.0 mg/mL

Auteur

Johnson & Johnson

Chaîne SMILES 

Cl[H].Cl[H].NC(=O)C1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)N3CCCCC3

InChI

1S/C21H30FN3O2.2ClH/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25;;/h6-9H,1-5,10-16H2,(H2,23,27);2*1H

Clé InChI

BMXXSXQVMCXGJM-UHFFFAOYSA-N

Application

Pipamperone dihydrochloride may be used:
  • as an internal standard in liquid chromatography with coulometric detection
  • as an antipsychotic drugs to test its interaction with human ether-a-go-go-related gene (hERG) channel
  • as an internal standard to spike human colostrum samples for reversed phase liquid chromatography- ultraviolet (LC-UV) analysis

Actions biochimiques/physiologiques

Pipamperone, a butyrophenone derivative is a pharmacological chaperone and is a membrane-permeable dopamine receptor D4 (DRD4) antagonist. The affinity of pipamperone is higher for DRD4 and 5-hydroxytryptamine 2A receptor (5-HT2A) in comparison with DRD2. It may be useful therapeutic in treating behavioral disorders and psychomotor agitation symptoms.
D2 dopamine receptor antagonist; 5-HT2 serotonin receptor antagonist; antipsychotic.

Caractéristiques et avantages

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

M Schwaninger et al.
Clinical neuropharmacology, 21(6), 344-346 (1998-12-09)
Hypothermia is a potentially life-threatening emergency. This article examines the case of a 34-year-old, mentally retarded man who experienced three episodes of hypothermia during recurrent exposure to pipamperone. After the pipamperone dose was largely reduced, no further hypothermic episodes occurred.
K Nisijima et al.
Brain research, 890(1), 23-31 (2001-02-13)
The serotonin (5-HT) syndrome is the most serious side effect of antidepressants, and it often necessitates pharmacotherapy. In the present study, the efficacy of several drugs was evaluated in an animal model of the 5-HT syndrome. When 2 mg/kg of
J E Belgaied et al.
Journal of pharmaceutical and biomedical analysis, 30(4), 1417-1423 (2002-11-01)
The electrochemical reduction of pipamperone has been carried out in aqueous solution in KNO(3) (0.1 mol l(-1)) by differential-pulse polarography (DPP). Pipamperone exhibits a well-defined irreversible reduction peak at -1.3 V/ref. The influence of pH on the reduction of pipamperone
Maria Addolorata Saracino et al.
Talanta, 81(4-5), 1547-1553 (2010-05-06)
A new analytical method, based on the use of liquid chromatography with coulometric detection, has been developed and applied to quantify risperidone and its main active metabolite 9-hydroxyrisperidone in human plasma and saliva. The analytes were separated on a reversed
Hypothermia in a patient with Alzheimer's disease receiving a combination therapy with risperidone and pipamperone.
Daniel Kamp et al.
Therapeutic advances in psychopharmacology, 6(1), 55-57 (2016-02-26)
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