P1499

Pterostilbene

≥97% (HPLC), solid

• Synonyme(s) : Pterocarpus marsupium, 3,5-Dimethoxy-4′-hydroxystilbene, 4-[(1E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol
• Formule empirique (notation de Hill): C₁₆H₁₆O₃
• Numéro CAS: 537-42-8
• Poids moléculaire : 256.30
• Numéro MDL: MFCD00238710
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724573
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥97% (HPLC)
• Forme: solid
• Conditions de stockage: protect from light
• Solubilité: DMSO: >20 mg/mL; H₂O: insoluble
• Température de stockage: 2-8°C
• Chaîne SMILES: COc1cc(OC)cc(\C=C\c2ccc(O)cc2)c1
• InChI: 1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
• Clé InChI: VLEUZFDZJKSGMX-ONEGZZNKSA-N

Description

Description générale

Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene), an antioxidant is an analogue of resveratrol. It is present in blueberries, tree wood and some types of grapes.

Application

Pterostilbene has been used:

• to investigate its anti-oxidative stress activities and the involvement of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) signaling pathway
• to determine its effects on transcriptional activation of estrogen receptor-α (ERα) in hormone resistant breast cancer cells)
• to study its effects on the cytotoxicity of 2-chloroethyl ethyl sulphide (CEES) in human epidermoid carcinoma cells (A-431) through MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide)viability assay

Actions biochimiques/physiologiques

Antioxidant, antiproliferative, apoptosis inducer, antihyperglycemic, antidiabetic.

Pterostilbene exhibits antineoplastic properties in some of the malignancies, hence it is considered as an active anticancer agent. It has the ability to stimulate apoptosis and block the viability of cell in estrogen-receptor positive and negative breast cancer cell lines.

Attention

Air-sensitive

Informations sur la sécurité

• Pictogrammes: GHS05,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H318,H411
• Conseils de prudence: P273 - P280 - P305 + P351 + P338 + P310
• Classification des risques: Aquatic Chronic 2 - Eye Dam. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves