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P1093

Sigma-Aldrich

Monoclonal Anti-Paxillin antibody produced in mouse

clone PXC-10, ascites fluid

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About This Item

Numéro MDL:
MFCD00212475
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

ascites fluid

Type de produit anticorps

primary antibodies

Clone

PXC-10, monoclonal

Poids mol.

antigen 68-40 kDa

Contient

15 mM sodium azide

Espèces réactives

bovine, rat, human, chicken, hamster

Technique(s)

immunocytochemistry: suitable
microarray: suitable
western blot: 1:500 using a cultured human cell line extract

Isotype

IgG1

Numéro d'accès UniProt

P49023

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... PXN(5829)
rat ... Pxn(360820)

Description générale

Monoclonal Anti-Paxillin (mouse IgG1 isotype) is derived from the PXC-10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Paxillin (68 kDa), is a cytoskeletal component. It is found in the ends of actin stress fibers of the focal adhesions, but not in adherens junctions of the cells. The paxillin molecule has a single binding site for vinculin, and at least two binding sites for focal adhesion kinase (FAK), that are separated by an intervening sequence of 100 amino acids.

Spécificité

Recognizes an epitope located in the LIM1 domain of the paxillin molecule.

Immunogène

C-terminal part of recombinant chicken paxillin (amino acids 305-559)

Application

Monoclonal Anti-Paxillin antibody produced in mouse has been used in immunoblotting and immunocytochemistry.

Actions biochimiques/physiologiques

Paxillin interacts with several proteins including members of the src family of tyrosine kinases, the transforming protein v-crk, the cytoskeletal protein vinculin, and the tyrosine kinase, focal adhesion kinase (FAK). This interaction has suggested a function for paxillin as a molecular adaptor, responsible for the recruitment of structural and signaling molecules to focal adhesions.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Paxillin: a crossroad in pathological cell migration
Lopez CAM, et al.
Journal of Hematology & Oncology, 10(1), 50-50 (2017)
Paxillin: a new vinculin-binding protein present in focal adhesions.
Turner CE, et al.
The Journal of cell biology, 111(3), 1059-1068 (1990)
Nien-Yi Chiang et al.
The Journal of biological chemistry, 286(16), 14215-14225 (2011-02-26)
Loss-of-function mutations in the gene encoding G protein-coupled receptor 56 (GPR56) lead to bilateral frontoparietal polymicrogyria (BFPP), an autosomal recessive disorder affecting brain development. The GPR56 receptor is a member of the adhesion-GPCR family characterized by the chimeric composition of
Emmanuella Tsirimonaki et al.
Virus research, 115(2), 158-168 (2005-09-20)
Bovine papillomaviruses (BPVs) are oncogenic viruses. In cattle, BPV-1/2 is associated with urinary bladder cancer and BPV-4 with upper GI tract cancer. BPV E5 is a small hydrophobic protein localised in the endoplasmic reticulum (ER) and Golgi apparatus (GA). E5
Vanessa Liévin-Le Moal et al.
Cellular microbiology, 13(7), 992-1013 (2011-04-20)
The secreted autotransporter toxin, Sat, which belongs to the subfamily of serine protease autotransporters of Enterobacteriaceae, acts as a virulence factor in extraintestinal and intestinal pathogenic strains of Escherichia coli. We observed that HeLa cells exposed to the cell-free culture
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