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O9765

Sigma-Aldrich

Orientin

≥97% (HPLC)

Synonyme(s) :

8-β-D-Glucopyranosyl-3′,4′,5,7-tetrahydroxyflavone, Luteolin 8-C-β-D-glucopyranoside, Luteolin-8-glucoside, Lutexin

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About This Item

Formule empirique (notation de Hill):
C21H20O11
Numéro CAS:
28608-75-5
Poids moléculaire :
448.38
Numéro MDL:
MFCD00017432
Code UNSPSC :
12352205
ID de substance PubChem :
329818945
Nomenclature NACRES :
NA.25

Pureté

≥97% (HPLC)

Forme

powder

Couleur

yellow

Solubilité

1 M NaOH: 1 mg/mL, clear, yellow-orange

Application(s)

metabolomics
vitamins, nutraceuticals, and natural products

Température de stockage

2-8°C

Chaîne SMILES 

OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c2c(O)cc(O)c3C(=O)C=C(Oc23)c4ccc(O)c(O)c4

InChI

1S/C21H20O11/c22-6-14-17(28)18(29)19(30)21(32-14)16-11(26)4-10(25)15-12(27)5-13(31-20(15)16)7-1-2-8(23)9(24)3-7/h1-5,14,17-19,21-26,28-30H,6H2/t14-,17-,18+,19-,21+/m1/s1

Clé InChI

PLAPMLGJVGLZOV-VPRICQMDSA-N

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Description générale

Orientin (ORI) is a luteolin derivative and water soluble 8-C-glucoside dietary flavone. It has one ketone, two ether, and phenyl groups in its chemical structure. Orientin is sourced from many medicinal plants such as Ocimum sanctum (holy basil), Phyllostachys species (bamboo leaves), Passiflora species, Trollius species, etc.

Application

Orientin has been used:
  • as an anti-inflammatory and anti-proliferative agent to test its protective effects against 1,2-dimethyl hydrazine (DMH)-induced colorectal cancer in rats model
  • as a flavanoid to investigate its protective effects against mitochondrial dysfunction on antimycin-A induced murine C2C12 skeletal muscle cells
  • as a potential endonuclease inhibitor of influenza polymerase PA subunit

Actions biochimiques/physiologiques

Orientin displays neuroprotective effects against hydrogen peroxide-induced SH-SY5Y neuroblastoma cells. It exerts antioxidant, anti-inflammation, antiaging, antidepressant-like, vasodilation, vasorelaxant, and cardioprotective effects.
Flavonoid glycoside found in the acai tree and globe and passion flowers. Antiviral, antimicrobial and antioxidant. Exhibits radioprotective activities.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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A Rovirosa et al.
Acta neurologica Belgica, 92(1), 30-35 (1992-01-01)
Meningeal Fibrosarcoma (MF) accounts only for 0.5% of the brain tumors. Since the clinical manifestations and radiologic findings are non-specific, the diagnosis can only be achieved by pathological examination of surgically removed specimens. MF are tumors that behave locally very
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Molecules (Basel, Switzerland), 26(20) (2021-10-24)
The current study investigated the physiological effects of flavonoids found in daily consumed rooibos tea, aspalathin, isoorientin, and orientin on improving processes involved in mitochondrial function in C2C12 myotubes. To achieve this, C2C12 myotubes were exposed to a mitochondrial channel
Kalaiyarasu Thangaraj et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 96, 1253-1266 (2017-12-05)
Orientin, a C-glycosyl dietary flavone profusely found in rooibos tea and passion fruit have gained much attention owing to their multiple pharmacological potentials. The present study intends to investigate the anti-proliferative and anti-inflammatory efficacy of Orientin in 1,2-dimethyl hydrazine (DMH)
Benjamin Ngee Tiing Law et al.
Molecular medicine reports, 9(3), 947-954 (2013-12-25)
Neurodegenerative diseases remain a global issue which affects the ageing population. Efforts towards determining their aetiologies to understand their pathogenic mechanisms are underway in order to identify a pathway through which therapeutic measures can be applied. One such pathogenic mechanism
Detection of atrial tachyarrhythmias by transesophageal pacing and recording at rest and during exercise in children with ventricular preexcitation.
F Drago et al.
The American journal of cardiology, 69(12), 1098-1099 (1992-04-25)
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