M2011

Melphalan

powder

• Synonyme(s) : 4-[Bis(2-chloroethyl)amino]-L-phenylalanine, L-PAM, L-Phenylalanine mustard
• Formule empirique (notation de Hill) : C₁₃H₁₈Cl₂N₂O₂
• Numéro CAS: 148-82-3
• Poids moléculaire : 305.20
• UNSPSC Code: 12352207
• NACRES: NA.32
• PubChem Substance ID: 24278538
• EC Number: 205-726-3
• Beilstein/REAXYS Number: 2816456
• MDL number: MFCD00057717
• Form: powder

Propriétés

• form: powder
• Quality Segment: 200
• color: white
• SMILES string: N[C@@H](Cc1ccc(cc1)N(CCCl)CCCl)C(O)=O
• InChI: 1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1
• InChI key: SGDBTWWWUNNDEQ-LBPRGKRZSA-N

Description

General description

Melphalan also known as L-phenylalanine mustard is an alkylating agent. It belongs to the class of nitrogen mustards, which act as chemotherapeutic agents.

Application

Melphalan has been used as a drug along with HDAC-inhibitor JNJ-26481585 to treat multiple myeloma (MM) in cell lines and as a chemotherapeutic agent for breast cancer cell line.

Biochem/physiol Actions

In rat, melphalan in isolated lung perfusion (ILP) functions as a potent therapeutics for sarcomatous pulmonary metastases. It forms DNA intrastrand crosslinks by bifunctional alkylation in 5′-GGC sequences. Melphalan acts as a bone-marrow depressant and is implicated in the treatment of multiple myeloma and ovarian cancer.

Melphalan is an antineoplastic agent.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mot-clé: Danger
• Codes de danger: H300,H317,H340,H350,H361
• Mentions de précaution: P201 - P280 - P301 + P310 + P330 - P302 + P352
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 1A - Muta. 1B - Repr. 2 - Skin Sens. 1
• Classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• EPI (équipement de protection individuelle): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges