HPA049580
Anti-CDX2 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody
Synonyme(s) :
CDX3
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About This Item
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Gamme de produits
Prestige Antibodies® Powered by Atlas Antibodies
Forme
buffered aqueous glycerol solution
Espèces réactives
human
Technique(s)
immunofluorescence: 0.25-2 μg/mL
Séquence immunogène
PGPLRSVPEPLSPVSSLQASVPGSVPGVLGPTGGVLNPTVT
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... CDX2(1045)
Description générale
Caudal type homeobox 2 (CDX2) is a member of caudal-related homeobox transcription factor gene family. Cdx2 is homologous to Drosophila developmental gene caudal. The Cdx2 gene is located on the human chromosome on 13q12.2. It is prominently produced in the intestine.
Immunogène
caudal type homeobox 2
Application
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-CDX2 antibody recognises CDX2 protein.
Actions biochimiques/physiologiques
Caudal type homeobox 2 (CDX2) plays a key role during early developmental stages by providing positional information for gastrointestinal tract, especially the midgut region. Cdx2 promotes proliferation and differentiation of intestinal epithelial cells. Cdx2 has tumour suppression function in colon cancer cells. Cdx2 expression level is found to decrease as the cancer advances from dysplasia to advanced gastric cancer. Abnormal amplification and upregulation of Cdx2 leads to colorectal cancer.
Caractéristiques et avantages
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Liaison
Corresponding Antigen APREST91202
Forme physique
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Informations légales
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development
Bonhomme C, et al.
Gut, 52(10), 1465-1471 (2003)
Cloning and chromosome assignment of the human CDX2 gene
Drummond F, et al.
Annals of Human Genetics, 61(5), 393-400 (1997)
CDX2 is an amplified lineage-survival oncogene in colorectal cancer
Salari K, et al.
Proceedings of the National Academy of Sciences of the USA, 61(5), 201206004-201206004 (2012)
Vasty Osei Amponsa et al.
American journal of clinical and experimental urology, 7(3), 139-152 (2019-07-19)
Creation of genetically engineered mouse models of bladder cancer often involves the use of several background strains in conjunction with the carcinogen N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN). However, carcinogen susceptibility in commonly used strains, as well as phenotypic differences is not well
CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance
Srivastava A, et al.
Modern Pathology, 23(1), 54-54 (2010)
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