G4386

γ-Globulins from human blood

≥99% (electrophoresis)

• Synonyme(s) : Human γ-Globulin
• Numéro CAS: 9007-83-4
• Numéro MDL: MFCD00164089
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.61

Propriétés

• Source biologique: human blood
• Pureté: ≥99% (electrophoresis)
• Forme: powder
• Technique(s): protein quantification: suitable
• Impuretés: HIV, HCV and HBsAg, source material tested negative; ≤4% NaCl
• Solubilité: 0.9% NaCl: soluble 50 mg/mL
• Numéro d'accès UniProt: P15814
• Température de stockage: 2-8°C
• Informations sur le gène: human ... IGLL1(3543)

Description

Description générale

γ-Globulins are immunoglobulins and occur in five classes, namely: IgG, IgM, IgA, IgD, and IgE. These are glycoproteins that are antibodies produced by plasma cells. The immunoglobulins are heterogeneous molecules made up of four polypeptide chains (two light chains and two heavy chains) linked together by disulfide bonds. The antigen-binding site is present at the nitrogen terminal. 20% of the protein in plasma are immunoglobulins.

Application

γ-Globulins from human blood have been used for the blocking step in cytometric bead array It has also been used as a standard for γ-globulin measurement in cerebrospinal fluid (CSF).

γ-globulins were used to study a micro-method for measuring total protein in cerebrospinal fluid by using benzethonium chloride in microtiter plate wells. It was used in the measurement of protein in tannin-protein precipitates using ninhydrin. It was also used to study the blood distribution of levocetirizine, a new non-sedating histamine H1-receptor antagonist, in humans.

Actions biochimiques/physiologiques

Immunoglobulins are key regulators of the immune system and are produced in response to antigens. They protect our bodies against bacteria, viruses, and fungi. Immunoglobulins are involved in the activation of the complement system, opsonization of microbes for phagocytosis, neutralization of toxins and viruses, and inhibition of the attachment of microbes to mucosal surfaces. Immunodeficiency can lead to recurrent infectious diseases.

Notes préparatoires

Prepared from Cohn Fraction II, III

Clause de non-responsabilité

Ce produit, destiné à la recherche scientifique, est soumis à une réglementation spécifique en France, y compris pour les activités d′importation et d′exportation (Article L 1211-1 alinéa 2 du Code de la Santé Publique). L′acheteur (c′est-à-dire l′utilisateur FINAL) est tenu d′obtenir une autorisation d′importation auprès du ministère français de la recherche, mentionné à l′article L1245-5-1 II du Code de la Santé Publique. En commandant ce produit, vous confirmez détenir l′autorisation d′importation requise.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable