According to McGowan, E. B. et al., Biochem. Biophys. Res. Comm., 158(2), 432-435 (1989), this compound was dissolved in DMSO up to 200 mg/mL for use as an inhibitor of calpain in both intact and lysed platelets..
E8640
E-64d
powder, ≥98% (TLC)
Synonyme(s) :
(2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester, EST
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About This Item
Formule empirique (notation de Hill):
C17H30N2O5
Numéro CAS:
Poids moléculaire :
342.43
Numéro MDL:
Code UNSPSC :
12352202
ID de substance PubChem :
Nomenclature NACRES :
NA.77
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Nom du produit
E-64d, protease inhibitor
Source biologique
synthetic (organic)
Niveau de qualité
Essai
≥98% (TLC)
Forme
powder
Solubilité
methanol: water (1:1): 5 mg/mL, clear, colorless
Température de stockage
−20°C
Chaîne SMILES
CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C
InChI
1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1
Clé InChI
SRVFFFJZQVENJC-IHRRRGAJSA-N
Informations sur le gène
human ... CAPN1(823)
Application
Actions biochimiques/physiologiques
E-64d is an epoxysuccinyl peptide and an inhibitor of cysteine protease cathepsin B,[4] calpains 1 and 2.[5] E-64d by its cathepsin B protease inhibition functionality, may serve as a potential drug for treating traumatic brain injury (TBI)[5] and Alzheimer′s disease (AD).[6] It inhibits gametocyte surface antigen resulting in a decreased oocyst production in Plasmodium falciparum.[7]
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
dust mask type N95 (US), Eyeshields, Gloves
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Lot/Batch Number
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Les clients ont également consulté
John P Lloyd et al.
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Extensive transcriptional activity occurring in intergenic regions of genomes has raised the question whether intergenic transcription represents the activity of novel genes or noisy expression. To address this, we evaluated cross-species and post-duplication sequence and expression conservation of intergenic transcribed
Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation
Yamada D, et al.
Biochemical and Biophysical Research Communications, 471(1), 109-116 (2016)
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Scientific reports, 7(1), 13354-13354 (2017-10-19)
A cDNA library from a pool of all the seven silk glands from a tropical spider species was constructed. More than 1000 expressed sequence tag (EST) clones were created. Almost 65% of the EST clones were identified and around 50%
E64d, a membrane-permeable cysteine protease inhibitor, attenuates the effects of parathyroid hormone on osteoblasts in vitro
Murray EJ, et al.
Metabolism and Disease, 46(9), 1090-1094 (1997)
The cysteine protease inhibitor, E64d, reduces brain amyloid-beta and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, beta-secretase activity
Hook G, et al.
Journal of Alzheimer'S Disease, 26(2), 387-408 (2011)
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What can I dissolve Product E8640, E-64d, in?
1 answer-
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Where can solutions of Product E8640, E-64d, be stored?
1 answer-
According to McGowan, E. B. et al., Biochem. Biophys. Res. Comm., 158(2), 432-435 (1989), solutions made in DMSO were stored at -70°C.
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What is the difference between E-64, E-64c and E-64d?
1 answer-
E-64c is a synthetic analog of E-64. E-64d is the ethyl ester of E-64c. E-64c is not cell permeable, but E-64d is cell permeable. E-64d is hydrolyzed in cell culture to E-64c.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How does the storage temperature relate to shipping conditions?
1 answer-
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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