E2387

NECA

≥98% (TLC), powder, adenosine receptor agonist

• Synonyme(s) : NECA
• Formule empirique (notation de Hill) : C₁₂H₁₆N₆O₄
• Numéro CAS: 35920-39-9
• Poids moléculaire : 308.29
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277684
• NACRES: NA.77
• MDL number: MFCD00069195
• Form: powder

Propriétés

• Nom du produit: 5′-(N-Ethylcarboxamido)adenosine, powder
• form: powder
• Quality Segment: 200
• color: white
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL (Solutions may be stored for several days at 4 °C.), DMSO: 14 mg/mL (Solutions may be stored for several days at 4 °C.), 0.1 M HCl: 3.4 mg/mL (Solutions may be stored for several days at 4 °C.), H₂O: insoluble, ethanol: soluble (Solutions may be stored for several days at 4 °C.)
• storage temp.: 2-8°C
• SMILES string: CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
• InChI: 1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1
• InChI key: JADDQZYHOWSFJD-FLNNQWSLSA-N
• Gene Information: human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140) ; rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Adora3(25370)

Description

General description

5′-(N-Ethylcarboxamido)adenosine stimulates vasodilation in the pulmonary circulation through A₂-adenosine-receptor activation.

Application

5′-(N-Ethylcarboxamido)adenosine has been used:

• for the purification of human adenosine A_2Areceptor (A_2AR) in decylmaltoside (DM)
• to determine nonspecific binding of adenosine receptors
• to investigate adenosine 2B receptor (RA2B) mechanism of action by competition assay

Biochem/physiol Actions

Potent adenosine receptor agonist with nearly equal affinity at A₁ and A₂ receptors.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• pictograms: GHS06
• signalword: Danger
• hcodes: H300
• pcodes: P264 - P301 + P310
• Hazard Classifications: Acute Tox. 2 Oral
• Classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges