D1262

P¹,P⁴-Di(adenosine-5′) tetraphosphate ammonium salt

≥95% (HPLC), powder

• Synonyme(s) : A(5′)p4(5′)A, Diadenosine tetraphosphate ammonium salt
• Formule empirique (notation de Hill): C₂₀H₂₈N₁₀O₁₉P₄ · xNH₃
• Numéro CAS: 102783-36-8
• Poids moléculaire : 836.39 (free acid basis)
• Numéro MDL: MFCD00058622
• Code UNSPSC : 41106305
• eCl@ss : 32160414
• ID de substance PubChem : 24277711
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥95% (HPLC)
• Forme: powder
• Couleur: white to off-white
• Solubilité: H₂O: 50 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: N.Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n5cnc6c(N)ncnc56)[C@@H](O)[C@H]3O
• InChI: 1S/C20H28N10O19P4.H3N/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(45-19)1-43-50(35,36)47-52(39,40)49-53(41,42)48-51(37,38)44-2-8-12(32)14(34)20(46-8)30-6-28-10-16(22)24-4-26-18(10)30;/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42)(H2,21,23,25)(H2,22,24,26);1H3/t7-,8-,11-,12-,13-,14-,19-,20-;/m1./s1
• Clé InChI: JTLRVYSRZSPJKJ-AHKIGRPSSA-N
• Informations sur le gène: human ... PLD1(5337) , PLD2(5338) , PLD3(23646) , PLD4(122618) , PLD5(200150)

Description

Application

P1,P4-Di(adenosine-5′) tetraphosphate ammonium salt has been used as a substrate for nudix hydrolyse. It has also been used as a ATP analog and nudix substrate for cleavage factor II Im25 subunit.

Actions biochimiques/physiologiques

Diadenosine polyphosphate (Ap4A) functions as a second messenger in pancreatic cells. Diadenosine polyphosphate is majorly stored in neuronal cells, thrombocytes and chromaffin. It stimulates phospholipase D, fluctuates intracellular calcium levels, induces nitric oxide release, activates 5′-nucleotidase, and inhibits adenosine kinase activity in vitro. The membrane-bound ectoenzymes in endothelial cells in blood plasma and smooth muscle cell metabolize Ap4A.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)