D048

MPP⁺ iodide

≥98% (HPLC), ERα antagonist, powder

• Synonyme(s) : 1-Methyl-4-phenylpyridinium iodide
• Formule empirique (notation de Hill) : C₁₂H₁₂IN
• Numéro CAS: 36913-39-0
• Poids moléculaire : 297.13
• UNSPSC Code: 12352200
• PubChem Substance ID: 24893235
• NACRES: NA.77
• MDL number: MFCD00055096
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Propriétés

• Nom du produit: MPP⁺ iodide, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 10 mg/mL, clear
• SMILES string: [I-].C[n+]1ccc(cc1)-c2ccccc2
• InChI: 1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
• InChI key: RFDFRDXIIKROAI-UHFFFAOYSA-M

Description

General description

1-Methyl-4-phenylpyridinium (MPP+) acts as a selective ERα antagonist.induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.

Application

MPP+ iodide has been used:

• to induce oxidative stress in zebrafish embryos
• for the inhibition of glutamate uptake in mitochondria of astrocytes
• in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells

Biochem/physiol Actions

Active metabolite of dopaminergic neurotoxin MPTP

MPP⁺ iodide is an active metabolite of dopaminergic neurotoxin MPTP.

Preparation Note

Solutions should be freshly prepared.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Disclaimer

Photosensitive.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mot-clé: Danger
• Codes de danger: H301 + H311 + H331,H315,H319,H335
• Mentions de précaution: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• EPI (équipement de protection individuelle): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges