The impurities that may be present in this product have not been identified. These impurites may include water and salts reminaining following the purification process.
C2755
Cortisone
≥95%
Synonyme(s) :
17α,21-Dihydroxy-4-pregnene-3,11,20-trione, 17α-Hydroxy-11-dehydrocorticosterone, 4-Pregnene-17α,21-diol-3,11,20-trione, Kendall’s Compound E, Reichstein’s Substance Fa
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About This Item
Formule empirique (notation de Hill):
C21H28O5
Numéro CAS:
Poids moléculaire :
360.44
Beilstein:
1356062
Numéro CE :
Numéro MDL:
Code UNSPSC :
51111800
ID de substance PubChem :
Nomenclature NACRES :
NA.77
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Source biologique
synthetic
Niveau de qualité
Stérilité
non-sterile
Essai
≥95%
Forme
powder
Technique(s)
inhibition assay: suitable
Pf
223-228 °C (dec.) (lit.)
Solubilité
chloroform: methanol (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
Conditions d'expédition
ambient
Température de stockage
room temp
Chaîne SMILES
C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)CC(=O)[C@H]23
InChI
1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
Clé InChI
MFYSYFVPBJMHGN-ZPOLXVRWSA-N
Informations sur le gène
human ... SERPINA6(866)
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Catégories apparentées
Application
Actions biochimiques/physiologiques
Cortisone (11 dehydro 17 hydroxycortico-sterone) is an anti-inflammatory glucocorticoid that delays wound healing after surgeries. It postpones the healing process by affecting the appearance of inflammatory cells, ground substance, fibroblasts, collagen, regenerating capillaries, and epithelial migration.[4] Glucocorticoids have anti-inflammatory, anti-allergic and immunosuppressive properties and are extensively used in treatment and therapy.[5]
Cortisone is a glucocorticoid; a corticosterone analog that has approximately twice the anti-inflammatory potency as corticosterone but much lower Na2+ retention potency.
Conditionnement
Bottomless glass bottle. Contents are inside inserted fused cone.
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Repr. 2
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Les clients ont également consulté
S McMullen et al.
Reproduction (Cambridge, England), 127(6), 717-725 (2004-06-04)
In the placenta, cortisol is inactivated by NADP(+)- and NAD(+)-dependent isoforms of 11beta-hydroxysteroid dehydrogenase (11betaHSD). Decreased placental 11betaHSD activities have been implicated in intrauterine growth restriction (IUGR) and fetal programming of adult diseases. The objective of this study was to
Jean-Sébastien Raul et al.
Clinical biochemistry, 37(12), 1105-1111 (2004-12-14)
Since the 1960s, glucocorticoids are used by athletes to improve their performances. Their use is restricted in sports. Hair can document chronic abuse and can be therefore a complementary matrix for doping control. We have developed a new extraction, purification
B Edwin et al.
Surgical endoscopy, 15(6), 589-591 (2001-10-10)
[corrected] We set out to record the operative times of an experienced laparoscopic team and assess the feasibility of outpatient laparoscopic adrenalectomy when optimal anesthesia was also offered to all patients. The study included 13 patients with aldosterone/cortisone hypersecretion and/or
Hengmiao Cheng et al.
Bioorganic & medicinal chemistry letters, 20(9), 2897-2902 (2010-04-07)
The design and development of a series of highly selective pyrrolidine carboxamide 11beta-HSD1 inhibitors are described. These compounds including PF-877423 demonstrated potent in vitro activity against both human and mouse 11beta-HSD1 enzymes. In an in vivo assay, PF-877423 inhibited the
F Zalman et al.
The Journal of experimental medicine, 149(1), 67-72 (1979-01-01)
The sensitivity of erythropoietic (BFU-E) and granulopoietic (CFU-C) progenitor cells to dexamethasone and cortisone was studied in cultures of mouse bone marrow. Although the log dose-response relationships had a similar form, the BFU-E were much more sensitive than the CFU-C
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What kind of impurities this product consists? According assays it is ≥95% cortisone. What compounds are included in remaining 5%?
1 answer-
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