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53271

Sigma-Aldrich

Mito Red

suitable for fluorescence, ≥70% (HPLC)

Synonyme(s) :

3,6-Bis(diethylamino)-9-[2-(4-methylcoumarin-7-yloxycarbonyl)phenyl]xanthylium chloride, Rhodamine B 4-methylumbelliferyl ester chloride

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About This Item

Formule empirique (notation de Hill):
C38H37ClN2O5
Numéro CAS:
1021902-10-2
Poids moléculaire :
637.16
Numéro MDL:
MFCD05664720
Code UNSPSC :
41116100
ID de substance PubChem :
329757927
Nomenclature NACRES :
NA.32

Pureté

≥70% (HPLC)

Forme

solid

Fluorescence

λex 569 nm; λem 594 nm in DMSO

Adéquation

suitable for fluorescence

Température de stockage

2-8°C

Chaîne SMILES 

[Cl-].CCN(CC)c1ccc2c(-c3ccccc3C(=O)Oc4ccc5C(C)=CC(=O)Oc5c4)c6ccc(cc6[o+]c2c1)N(CC)CC

InChI

1S/C38H37N2O5.ClH/c1-6-39(7-2)25-14-17-31-33(21-25)44-34-22-26(40(8-3)9-4)15-18-32(34)37(31)29-12-10-11-13-30(29)38(42)43-27-16-19-28-24(5)20-36(41)45-35(28)23-27;/h10-23H,6-9H2,1-5H3;1H/q+1;/p-1

Clé InChI

XCVSDCPWJRHMSZ-UHFFFAOYSA-M

Description générale

Mito Red is a cell membrane permeable rhodamine based dye. It localizes mitochondria, and emits red fluorescence. The interaction of Mito Red with mitochondria depends of the membrane potential of the mitochondria. Mitochondria can be stained with 20-200 nM of Mito Red.

Application

MitoRed (Mito Red), a vital dye and mitochondrial stain, is used to indicate the status of mitochondria under various physiological and physical conditions.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Taeko Horinouchi et al.
Bioorganic & medicinal chemistry letters, 21(7), 2000-2002 (2011-03-08)
We report a novel green-fluorescent NO donor, NBDNO, bearing a 2,6-dimethylnitrobenzene moiety for photocontrollable NO release and a triphenylphosphonium moiety for targeting to mitochondria. Photorelease of NO from NBDNO was confirmed by means of ESR analysis in aqueous solution. Intracellular
Mamoru Kobayashi et al.
Human cell, 21(1), 7-11 (2008-01-15)
We investigated the mitochondrial behavior, localization and heteroplasmy in reconstituted oocytes derived from germinal vesicle (GV) transfers. The karyoplast containing the GV nucleus and the ooplast (enucleated oocyte) were prepared from GV oocytes derived from B6D2F1 mice. Mitochondria in the
Wei-Lien Yen et al.
The Journal of cell biology, 188(1), 101-114 (2010-01-13)
Macroautophagy is a catabolic pathway used for the turnover of long-lived proteins and organelles in eukaryotic cells. The morphological hallmark of this process is the formation of double-membrane autophagosomes that sequester cytoplasm. Autophagosome formation is the most complex part of
M Di Carlo et al.
Journal of biomedicine & biotechnology, 2010, 147835-147835 (2010-05-22)
Alzheimer's disease (AD) and type 2 diabetes are connected in a way that is still not completely understood, but insulin resistance has been implicated as a risk factor for developing AD. Here we show an evidence that insulin is capable
Yumiko Nagano et al.
Digestive diseases and sciences, 50 Suppl 1, S76-S83 (2005-09-27)
Nonsteroidal antiinflammatory drugs (NSAIDs) cause complications such as gastrointestinal injury. NSAIDs were recently reported to cause mitochondrial injury: to dissipate the mitochondrial transmembrane potential (MTP), and to induce mitochondrial permeability transition pore (PTP), which liberates cytochrome c. This enzyme generates
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