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52471

Sigma-Aldrich

Isothiocyanate-dextrane marqué à la fluorescence

average mol wt 2,000,000

Synonyme(s) :

FITC-dextrane

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About This Item

Numéro CAS:
60842-46-8
Numéro MDL:
MFCD00131092
Code UNSPSC :
12352201
Nomenclature NACRES :
NA.32

Source biologique

synthetic

Niveau de qualité

100

Conjugué

FITC conjugate

Forme

powder or crystals

Poids mol.

average mol wt 2,000,000

Ampleur du marquage

0.001-0.020 mol FITC per mol glucose (substitution)

Fluorescence

λex 493 nm; λem 520 nm in 0.1 M Tris pH 8.0

Application(s)

cell analysis

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Catégories apparentées

Application

Dextrane marqué à l′isothiocyanate de fluorescéine pour utilisation potentielle dans les études de perfusion chez l′animal.
Fluorescein isothiocyanate–dextran (FITC–Dextran 2000) is use as a fluorescent probe to study the permeability of structures such as intercellular junctions involved in processes such as hearing and vascular permeability and the integrity of the blood brain barrier (BBB).

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Elodie Debefve et al.
Lasers in surgery and medicine, 43(7), 696-704 (2011-11-08)
Photodynamic therapy (PDT) affects vascular barrier function and thus increases vessel permeability. This phenomenon may be exploited to facilitate targeted drug delivery and may lead to a new clinical application of photodynamic therapy. Here, we investigate the role of leukocyte
Sung Ji Ahn et al.
Biomedical optics express, 11(5), 2665-2678 (2020-06-06)
We show that third harmonic generation (THG) microscopy using a 1-MHz train of 1,300-nm femtosecond duration laser pulses enabled visualization of the structure and quantification of flow speed in the cortical microvascular network of mice to a depth of >
Guiliang Zheng et al.
BMC neuroscience, 13, 71-71 (2012-06-21)
Exposure to intense noise causes the excessive movement of the organ of Corti, stretching the organ and compromising sensory cell functions. We recently revealed changes in the transcriptional expression of multiple adhesion-related genes during the acute phases of cochlear damage
Albert Y Jin et al.
BMC neuroscience, 11, 12-12 (2010-02-04)
The link between early blood- brain barrier (BBB) breakdown and endothelial cell activation in acute stroke remain poorly defined. We hypothesized that P-selectin, a mediator of the early phase of leukocyte recruitment in acute ischemia is also a major contributor
Sangmi Ock et al.
Biochemical and biophysical research communications, 516(2), 350-356 (2019-06-19)
Receptor activator of NF-κB ligand (RANKL) is a member of the TNF superfamily. RANKL increases endothelial permeability and induces angiogenesis, suggesting its critical roles in the vasculature. Despite the evidence implicating RANKL in vascular pathology, its role in ischemic retinopathy
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