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Sigma-Aldrich

Poly(éthylene glycol)-blocage-poly(propylène glycol)-blocage-poly(éthylene glycol)

purified, non-ionic

Synonyme(s) :

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)

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About This Item

Numéro CAS:
9003-11-6
Numéro MDL:
MFCD00082049
Code UNSPSC :
12352104
Nomenclature NACRES :
NA.25

Forme

powder

Qualité

purified

Impuretés

≤1.0% water

pH

5.0-7.5

Solubilité

soluble, clear, colorless

Traces de cations

Al: ≤5 mg/kg
As: ≤0.05 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤50 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤1000 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

Absorption UV

λ: 260 nm Amax: ≤0.3
λ: 280 nm Amax: ≤0..2

Adéquation

no residue for filter test

Température de stockage

2-8°C

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

Clé InChI

RVGRUAULSDPKGF-UHFFFAOYSA-N

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Description générale

Poloxamer 407 is a water-soluble, non-ionic surfactant with low toxicity and good solubilizing capacity. This triblock copolymer is composed of a hydrophobic residue of polyoxypropylene (POP) flanked by two hydrophilic units of polyoxyethylene (POE).

Application

Poloxamer 407 has been used:
  • as an inhibitor of lipoprotein lipase activity to assess hepatic very-low-density lipoprotein (VLDL)- triglyceride (TG) secretion in mice
  • for VLDL secretion assay in mice
  • to intraperitoneally inject the mice by dissolving in phosphate buffer saline (PBS) for hepatic triglyceride production

Actions biochimiques/physiologiques

Poloxamer 407 (P407) exhibits reversible gelation properties above a particular polymer concentration and temperature. Poloxamer 407-based sterile injectable formulations serve to be a good candidate for drug delivery. P407 thermo-responsive hydrogels are broadly used as mucosal drug delivery systems as they do not irritate the mucosal membranes. P407 is called an “inactive ingredient” by the U.S. Food and Drug Administration (FDA) for several drug products like oral solutions, suspensions, and inhalation formulations.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

08168

Timestrip Plus™ 8 °C

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Polyplex particles formed with plasmid DNA (pDNA) and Pluronic P85-block-poly{N-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} (P85-b-P[Asp(DET)]) demonstrated highly effective transfection ability compared to PEG-based block cationomer, PEG-b-P[Asp(DET)]. Ternary polyplexes comprising PEG-b-P[Asp(DET)], poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-b-P[Asp(DET)] (P(EPE)-b-P[Asp(DET)]) used as an analog of P85-b-P[Asp(DET)], and pDNA were
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