T176

4-Hydroxytamoxifène

analytical standard, (E) and (Z) isomers (50:50)

• Synonyme(s) : 4-(1-[4-(Diméthylaminoéthoxy)phényl]-2-phényl-1-butényl)phénol, 4-OHT, cis/trans-4-Hydroxytamoxifène
• Formule empirique (notation de Hill): C₂₆H₂₉NO₂
• Numéro CAS: 68392-35-8
• Poids moléculaire : 387.51
• Code UNSPSC : 41116107
• ID de substance PubChem : 24899989
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: analytical standard
• Niveau de qualité: 200
• Forme: powder
• Technique(s): HPLC: suitable; gas chromatography (GC): suitable
• Solubilité: ethanol: 20 mg/mL
• Spectre d'activité de l'antibiotique: neoplastics
• Application(s): forensics and toxicology; pharmaceutical (small molecule)
• Format: neat
• Mode d’action: enzyme | inhibits
• Chaîne SMILES: CC\C(c1ccccc1)=C(/c2ccc(O)cc2)c3ccc(OCCN(C)C)cc3.CC\C(c4ccccc4)=C(\c5ccc(O)cc5)c6ccc(OCCN(C)C)cc6
• InChI: 1S/2C26H29NO2/c2*1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h2*5-17,28H,4,18-19H2,1-3H3/b26-25+;26-25-
• Clé InChI: ZJLDABGSDWXVGE-BDSXMVAQSA-N
• Informations sur le gène: human ... ESR1(2099) , ESR2(2100) , ESRRG(2104) , IL6(3569) ; rat ... Ar(24208) , Esr1(24890) , Esr2(25149)

Description

Description générale

4-Hydroxytamoxifen is an antiestrogenic agent and one of the active metabolites of tamoxifen, formed upon its hydroxylation cytochrome P4502D6 (CYP2D6). Tamoxifen is used significantly in breast cancer as hormonal therapy.

Application

The 4-Hydroxytamoxifen analytical standard can be used as follows:

• Determination of tamoxifen and its three metabolites from dried blood spot (DBS) discs by ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS)
• Simultaneous estimation of tamoxifen, 4-hydroxytamoxifen, and endoxifen from DBS samples by UHPLC-MS/MS
• Development and validation of a non-aqueous capillary electrophoretic (NACE) method coupled with capacitively coupled contactless conductivity detection (C⁴D) to analyze tamoxifen and its three main metabolites after their liquid-liquid extraction (LLE) from human plasma samples obtained from breast cancer patients
• Multi-residue analysis of human plasma samples to quantify tamoxifen and its degradation products using the non-aqueous capillary electrophoretic (NACE) method combined with UV-detection
• Combined detection of tamoxifen and centchroman, along with their degradation products in human plasma samples by LC-ESI-MS/MS

Actions biochimiques/physiologiques

Métabolite du médicament de chimiothérapie tamoxifène, présentant une activité plus puissante d′agoniste/antagoniste des œstrogènes que la molécule mère. Présente également une activité d′inhibiteur de la peroxydation des lipides.

Autres remarques

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302 + H312 + H332,H315,H319,H361fd
• Conseils de prudence: P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges