S6501

Streptomycin sulfate salt

powder

• Synonyme(s) : 2-[(1S,2R,3R,4S,5R,6R)-5-(diaminomethylideneamino)-2-[(2R,3S,4S,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-methylamino-oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyl-oxolan-2-yl]oxy-3,4,6-trihydroxy-cyclohexyl]guanidine
• Formule linéaire : C₂₁H₃₉N₇O₁₂ · 1.5 H₂SO₄
• Numéro CAS: 3810-74-0
• Poids moléculaire : 728.69
• Beilstein: 3894995
• Numéro CE : 223-286-0
• Numéro MDL: MFCD00037023
• Code UNSPSC : 51281675
• ID de substance PubChem : 24899705
• Nomenclature NACRES : NA.76

Propriétés

• Source biologique: Streptomyces griseus
• Niveau de qualité: 200
• Forme: powder
• Puissance: ≥720 I.U. per mg
• Poids mol.: calculated mol wt 1457.38
• Conditions de stockage: (Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
• Couleur: white to off-white
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• Mode d’action: protein synthesis | interferes
• Température de stockage: 2-8°C
• Chaîne SMILES: OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N
• InChI: 1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1
• Clé InChI: QTENRWWVYAAPBI-YZTFXSNBSA-N

Description

Description générale

(C₂₁H₃₉N₇O₁₂)₂ ⋅3H₂O₄S

Chemical structure: aminoglycoside

Application

Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.

Actions biochimiques/physiologiques

Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.

Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.

Antimicrobial spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.

Attention

Solutions can be stored at 2-8°C for up to a month or at -20°C for more extended periods. At 37°C, solutions are stable for three days.

Notes préparatoires

Stock solutions should be prepared directly in the vial with sterile water at concentrations between 20-25 mg/mL.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H361fd
• Conseils de prudence: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Repr. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves