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Principaux documents

D2963000

Doxapram hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Doxapram hydrochloride monohydrate, 1-Ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone monohydrochloride monohydrate

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About This Item

Formule empirique (notation de Hill):
C24H30N2O2 · HCl · H2O
Numéro CAS:
7081-53-0
Poids moléculaire :
432.98
Numéro MDL:
MFCD09954698
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

doxapram

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

[Cl-].[N+H]4(CCOCC4)CCC1CN(C(=O)C1(c3ccccc3)c2ccccc2)CC.O

InChI

1S/C24H30N2O2.ClH.H2O/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21;;/h3-12,22H,2,13-19H2,1H3;1H;1H2

Clé InChI

ZOMBFZRWMLIDPX-UHFFFAOYSA-N

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Doxapram hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301

Classification des risques

Acute Tox. 3 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

James L Abelson et al.
Depression and anxiety, 25(10), 885-887 (2007-06-09)
Dysregulation within both respiratory control systems and the hypothalamic-pituitary adrenal (HPA) axis has been implicated in the pathophysiological of panic disorder. However, potential linkages between respiration and the HPA axis have rarely been examined in panic patients. We have previously
Kenneth Kearney et al.
Journal of pharmacological and toxicological methods, 62(2), 119-126 (2010-07-06)
The Safety Pharmacology ICH S7A guidelines mandate the preclinical evaluation of drug effects on respiratory function. Chronic measurements of potential drug effects are commonly performed in rodents due to lack of a viable alternative in large animals. Presently, although the
Joseph F Cotten
Anesthesia and analgesia, 116(4), 810-816 (2013-03-06)
TASK-1 and TASK-3 tandem pore potassium channel subunits provide a constitutive acidic pH- and hypoxia-inhibited potassium conductance. TASK channels are expressed in a number of tissues involved in regulation of breathing, and the TASK-1/TASK-3 heterodimer provides the predominant hypoxia-sensitive potassium
Towards evidence based emergency medicine:PRIVATE best BETs from the Manchester Royal Infirmary. Bet 2: doxapram resurrected? Weak evidence of efficacy suggests a potential use in patients ineligible for non-invasive ventilation.
Emergency medicine journal : EMJ, 29(1), 78-80 (2011-12-22)
Leith C R Meyer et al.
Journal of wildlife diseases, 46(2), 514-524 (2010-08-07)
Respiratory depression is a common side effect when opioids are used to immobilize wildlife. Serotonergic ligands have the potential to reverse opioid-induced respiratory depression. We examined whether any of three serotonergic ligands could reverse this depression in etorphine-immobilized (0.07 mg/kg)
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