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A0363000

Amantadine hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride, NSC 83653, Tricyclo[3.3.1.13,7]decan-1-amine hydrochloride

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About This Item

Formule empirique (notation de Hill):
C10H17N · HCl
Numéro CAS:
665-66-7
Poids moléculaire :
187.71
Numéro Beilstein :
4198854
Numéro MDL:
MFCD00074723
Code UNSPSC :
41116107
ID de substance PubChem :
329770607
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

amantadine

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3

InChI

1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;

Clé InChI

WOLHOYHSEKDWQH-SOVZANNPSA-N

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Amantadine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Dopamine releaser used to treat Parkinsonism and drug-induced extrapyramidal reactions.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

1018505

Amantadine hydrochloride, United States Pharmacopeia (USP) Reference Standard

1018516

Amantadine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1018527

Amantadine Related Compound B, United States Pharmacopeia (USP) Reference Standard

PHR1711

Amantadine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

BP530

Amantadine hydrochloride, British Pharmacopoeia (BP) Reference Standard

PHR2831

Amantadine Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2832

Amantadine Related Compound B, certified reference material, pharmaceutical secondary standard

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Conseils de prudence

P301 + P312 + P330

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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Consulter la Bibliothèque de documents

Amantadine hydrochloride: current and new uses.
S de Roin et al.
The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 22(5), 322-325 (1990-10-01)
S Ito et al.
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 38(12), 897-902 (2001-03-14)
A virus infection was studied using half of the normal oral dose of amantadine hydrochloride-100 mg/d instead of 200 mg/d. The patients in this study, who visited the clinics during January and February 1999, were confirmed within 48 hours to
Bo OuYang et al.
Biochimica et biophysica acta, 1838(4), 1058-1067 (2013-09-24)
Many viral genomes encode small, integral membrane proteins that form homo-oligomeric channels in membrane, and they transport protons, cations, and other molecules across the membrane barrier to aid various steps of viral entry and maturation. These viral proteins, collectively named
Matias Rey-Carrizo et al.
Journal of medicinal chemistry, 57(13), 5738-5747 (2014-06-19)
Amantadine inhibits the M2 proton channel of influenza A virus, yet most of the currently circulating strains of the virus carry mutations in the M2 protein that render the virus amantadine-resistant. While most of the research on novel amantadine analogues
R L Tominack et al.
Infectious disease clinics of North America, 1(2), 459-478 (1987-06-01)
Amantadine and rimantadine are oral antiviral drugs useful in the prophylaxis and treatment of influenza A virus infections. This article reviews the pharmacology, antiviral activity and mechanism of action, pharmacokinetics, toxicities, efficacy, and clinical applications of these agents. When administered
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