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N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane

with 1% trimethylchlorosilane, for GC derivatization, LiChropur™

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About This Item

Formule empirique (notation de Hill):
C6H12F3NOSi
Numéro CAS:
24589-78-4
Poids moléculaire :
199.25
Numéro Beilstein :
1941550
Numéro MDL:
MFCD00000411
Code UNSPSC :
12000000
ID de substance PubChem :
329761687
Nomenclature NACRES :
NA.22

product name

N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane, for GC derivatization, LiChropur™

Niveau de qualité

100

Qualité

for GC derivatization
LiChropur™

Pureté

≥97.0%

Forme

liquid

Pertinence de la réaction

reagent type: derivatization reagent
reaction type: Silylations

Technique(s)

gas chromatography (GC): suitable

Indice de réfraction

n20/D 1.378

Chaîne SMILES 

CN(C(=O)C(F)(F)F)[Si](C)(C)C

InChI

1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3

Clé InChI

MSPCIZMDDUQPGJ-UHFFFAOYSA-N

Catégories apparentées

Description générale

Silylation can be performed by adding N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MTFA) during analysis of fluorometabolites via gas chromatography-mass spectrometry (GC-MS).

Application

Addition of Trimethylchlorosilane aids in the derivatization of amides, secondary amines and hindered hydroxy groups. Most volatile of the TMS derivatives often elutes at the solvent front of the GC.

Informations légales

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

FlameExclamation mark
GHS02,GHS07

Mention d'avertissement

Warning

Mentions de danger

H226,H315,H319,H335

Classification des risques

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

78.8 °F - closed cup

Point d'éclair (°C)

26 °C - closed cup

Équipement de protection individuelle

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
BCCL2549
BCCG9280
BCCJ5812
BCCF5955
BCCC9855

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T6381

N,O-Bis(triméthylsilyl)trifluoroacétamide avec triméthylchlorosilane

Pyridine suitable for HPLC, ≥99.9%

Sigma-Aldrich

270407

Pyridine

Heneicosanoic acid analytical standard

Supelco

H5149

Heneicosanoic acid

Filamentous fungal biofilm for production of human drug metabolites.
Amadio, Jessica, Eoin Casey, and Cormac D. Murphy.
Applied Microbiology and Biotechnology, 97 (13), 5955-5963 (2013)
Hee-Kyung Jeon et al.
Journal of chromatography. A, 1131(1-2), 192-202 (2006-08-08)
A novel method has been developed to simultaneously determine and quantify seven organic UV filters employing liquid (solid)-liquid extraction, derivatization with N-methyl-N-(trimethylsilyl) trifluoroacetamide (MSTFA) and gas chromatography with mass spectrometric detection in various environmental matrices. The UV filters determined were:
Iria González-Mariño et al.
Journal of chromatography. A, 1217(11), 1748-1760 (2010-02-13)
An alternative method for the sensitive determination of several drugs of abuse and some of their metabolites in surface and sewage water samples is proposed. Analytes are concentrated using a solid-phase extraction (SPE) sorbent, converted into the corresponding trimethylsilyl derivatives
Harin Kanani et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 871(2), 191-201 (2008-06-10)
Metabolomics being the most recently introduced "omic" analytical platform is currently at its development phase. For the metabolomics to be broadly deployed to biological and clinical research and practice, issues regarding data validation and reproducibility need to be resolved. Gas
John A Bowden et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(27), 3237-3242 (2009-08-21)
Steroid derivatization was investigated by varying the experimental parameters (reagent, reaction time, and reaction temperature) to determine the optimal conditions for individual steroids, and for larger subsets. Three methods of derivatization enhancement were also investigated: the use of sonication, the
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Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

Silylation of Non-Steroidal Anti-Inflammatory Drugs

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

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