61188

Losartan Potassium

• Synonyme(s) : 2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt
• Formule empirique (notation de Hill): C₂₂H₂₂ClKN₆O
• Numéro CAS: 124750-99-8
• Poids moléculaire : 461.00
• Beilstein: 5845770
• Numéro MDL: MFCD02092704
• Code UNSPSC : 41116107
• ID de substance PubChem : 329759382
• Nomenclature NACRES : NA.24

Propriétés

• Forme: powder or crystals
• Niveau de qualité: 200
• Durée de conservation: limited shelf life, expiry date on the label
• Technique(s): HPLC: suitable; gas chromatography (GC): suitable
• Impuretés: ≤0.5% water
• Application(s): forensics and toxicology; pharmaceutical (small molecule); veterinary
• Chaîne SMILES: CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]
• InChI: 1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
• Clé InChI: OXCMYAYHXIHQOA-UHFFFAOYSA-N
• Informations sur le gène: human ... AGTR1(185)

Description

Description générale

Losartan potassium has long lasting effects, and its efficacy is generally increased, when combined with the diuretic co-active hydrochlorothiazide.[1]

Losartan potassium is an antihypertensive drug that is found to be an angiotensin II receptor type 1 blocker. It finds applications in reducing mechanical stress thereby having a control over the condition of cardiac hypertrophy.[2]

Application

Losartan potassium may be used as an analytical reference standard for the quantification of the analyte in the following:

• Pharmaceutical formulations using reversed-phase high-performance liquid chromatography[3][4][5] and UV-spectrophotometric techniques.[4]
• Rat plasma using liquid chromatography–tandem mass spectrometry (LC–MS/MS) technique.[6]

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Actions biochimiques/physiologiques

Losartan potassium is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan potassium is used for treatment of hypertension.

Produits recommandés

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)