Accéder au contenu
Merck
Toutes les photos(1)

Key Documents

View All Documentation

01338

Supelco

Bergamottin

analytical standard

Synonyme(s) :

Bergamotine, Bergaptin

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):
C21H22O4
Numéro CAS:
7380-40-7
Poids moléculaire :
338.40
Numéro Beilstein :
1353914
Numéro MDL:
MFCD00017409
Code UNSPSC :
85151701
ID de substance PubChem :
329747253
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

100

Pureté

≥98.0% (HPLC)

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Pf

75-80 °C

Application(s)

food and beverages

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

C\C(C)=C\CC\C(C)=C\COc1c2C=CC(=O)Oc2cc3occc13

InChI

1S/C21H22O4/c1-14(2)5-4-6-15(3)9-11-24-21-16-7-8-20(22)25-19(16)13-18-17(21)10-12-23-18/h5,7-10,12-13H,4,6,11H2,1-3H3/b15-9+

Clé InChI

DBMJZOMNXBSRED-OQLLNIDSSA-N

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Catégories apparentées

Description générale

Bergamottin, a member of the furanocoumarin family, is primarily found in grapefruit juice. It is reported to be a novel signal transducer and activator of the transcription 3 (STAT3) inhibitor. It is a known drug inhibitor of cytochrome P450 34A and also exhibits diverse anti-tumor and anti-inflammatory activities.

Application

Bergamottin may be used as an analytical standard to test its efficacy in the following:
  • Blocker of STAT3 activation pathway in tumor cells; its potential in the therapy of multiple myeloma (MM) and other cancers is investigated.
  • Prevention and the treatment of cancer via suppression of the NF-kB signaling pathway and its regulated gene products.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Produits recommandés

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
BCCL0244
BCCJ7166
BCCJ0282
BCCD6554
BCBV9499

Vous ne trouvez pas la bonne version ?

Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Rechercher un(e) COA

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 3

1 of 3

Xanthotoxin analytical standard

Supelco

56448

Xanthotoxin

5-Methoxypsoralen 99%

Sigma-Aldrich

275727

5-Methoxypsoralen

(±)-Citronellal analytical standard

Supelco

72638

(±)-Citronellal

Narue Sakamaki et al.
Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan, 49(4), 326-331 (2008-09-13)
Interactions between grapefruit juice and medications have long been recognized. In recent years, several furanocoumarins (FCs) that inhibit P450 activity in intestinal microsomes have been isolated from grapefruit juice. FCs, i.e., bergamottin (BG), bergapten (BP), bergaptol (BT) and 6',7'-dihydroxybergamottin (DHB)
Y Uesawa et al.
Die Pharmazie, 63(2), 110-112 (2008-04-03)
Bergamottin was identified as a cause of pharmacokinetic interaction with grapefruit juice intake and as a physiologically active substance involved in lipolysis. However, the quantification method on concentrations of bergamottin in systemic circulation has not been well established. The aim
Y Uesawa et al.
Die Pharmazie, 66(7), 525-528 (2011-08-05)
Grapefruit juice (GFJ) is known to affect the pharmacokinetics of a variety of drugs administered concomitantly and this is due to inhibition of intestinal CYP3A, a barrier protein for drug absorption. Some compounds such as furanocoumarin derivatives have been reported
Whocely Victor de Castro et al.
Journal of agricultural and food chemistry, 56(12), 4840-4845 (2008-05-23)
The effect of two varieties of grapefruit juice (white and ruby red) and its selected components (naringin, naringenin, and bergamottin) was investigated on the activity of the P-glycoprotein (P-gp) in male Sprague-Dawley rats. Talinolol, a nonmetabolized P-gp substrate, was used
Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells
Kim M-S, et al.
Cancer Cells, 354(01), 153-163 (2014)
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique