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Key Documents

MAB11041

Sigma-Aldrich

Anti-Serotonin receptor 1A Antibody, clone 19A9.2

clone 19A9.2, from mouse

Synonyme(s) :

5-hydroxytryptamine (serotonin) receptor 1A, 5-hydroxytryptamine receptor 1A, guanine nucleotide-binding regulatory protein-coupled receptor, Serotonin receptor 1A, G protein coupled receptor, 5-HT1a receptor

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

19A9.2, monoclonal

Espèces réactives

human, rat

Technique(s)

immunohistochemistry: suitable
western blot: suitable

Isotype

IgMκ

Numéro d'accès NCBI

NP_036717

Numéro d'accès UniProt

P19327

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... HTR1A(3350)
rat ... Htr1A(24473)

Description générale

Serotonin receptor 1A, also known as 5-hydroxytryptamine receptor 1A, is a member of the G protein-coupled receptor family. Serotonin receptor 1A has been found to be expressed highly in the septum and hippocampus. Serotonin receptor 1A seems to have an inhibitory effect on Ca2+ channels, via N-channels and L-channels. The receptor actuates voltage-sensitive slowing using the N-channels and actuates steady state inhibition using the L-channels.

Immunogène

KLH-conjugated linear peptide corresponding to rat Serotonin receptor 1A.

Application

Anti-Serotonin receptor 1A Antibody, clone 19A9.2 is an antibody against Serotonin receptor 1A for use in WB, IH.
Immunohistochemistry Analysis: 1:400 dilution from a previous lot detected Serotonin receptor 1A in normal human brain tissue.
Research Category
Neuroscience
Research Sub Category
Signaling Neuroscience

Qualité

Evaluated by Western Blot in rat brain tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Serotonin receptor 1A on 10 µg of rat brain tissue lysate.

Description de la cible

~40 kDa observed. The calculated molecular weight is 46 kDa

Forme physique

Format: Purified
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
Rat brain tissue lysate

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Emily J Reedich et al.
The Journal of physiology, 601(19), 4271-4289 (2023-08-16)
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Shaoyuan Li et al.
Molecular pain, 14, 1744806918787368-1744806918787368 (2018-06-21)
Painful neuropathy is a frequent comorbidity in diabetes. Zucker diabetic fatty (fa/fa) rats develop type 2 diabetes spontaneously with aging and show nociceptive hypersensitivity at the age of 13 weeks. In preclinical and clinical studies, the treatment of diabetic neuropathy
Laura García-Durán et al.
International journal of molecular sciences, 22(19) (2021-10-14)
Selective 5-HT reuptake inhibitor antidepressants (SSRIs) are the first choice in major depressive disorder (MDD), but 50% of affected patients do not show improvement. Galanin(1-15) [GAL(1-15)] enhanced Fluoxetine antidepressant-like effects in an animal model of depression, the olfactory bulbectomy (OBX);
Elenia Cinelli et al.
The European journal of neuroscience, 52(8), 3903-3917 (2020-05-08)
In mammals, 5-HTexcitatory respiratory effects imply 5-HT1A receptor-mediated disinhibition of pre-Bötzinger complex neurons. In the lamprey, 5-HT1A receptors are involved in the neural control of locomotion, but their role in the respiratory regulation, particularly at the level of the putative

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