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AB3704

Sigma-Aldrich

Anti-Orexin-A Antibody

serum, Chemicon®

Synonyme(s) :

Anti-NRCLP1, Anti-OX, Anti-PPOX

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

Forme d'anticorps

serum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

rat

Fabricant/nom de marque

Chemicon®

Technique(s)

immunohistochemistry: suitable

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... PPOX(5498)

Spécificité

Orexin-A.

Immunogène

Synthetic peptide corresponding to the C-terminal portion of the bovine Orexin-A peptide.

Application

Detect Orexin-A using this Anti-Orexin-A Antibody validated for use in IH.
Immunohistochemistry: 1:1,000-1:2,000. The antibody shows intense labeling of Orexin-A neurons with low background.

Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Research Sub Category
CNS Control of Metabolism

Circadian Rhythm & Sleep

Forme physique

Rabbit serum. Lyophilized. Reconstitute with 50 mL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative.

Stockage et stabilité

Maintain lyophilized material frozen at -20°C to -70°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

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Leigh-Anne Dell et al.
Journal of chemical neuroanatomy, 68, 61-76 (2015-08-02)
The species of the cetacean and artiodactyl suborders, which constitute the order Cetartiodactyla, exhibit very different sleep phenomenology, with artiodactyls showing typical bihemispheric slow wave and REM sleep, while cetaceans show unihemispheric slow wave sleep and appear to lack REM
Daniel S Wheeler et al.
The European journal of neuroscience, 40(2), 2359-2377 (2014-04-23)
Orexin (hypocretin) and melanin-concentrating hormone (MCH) neurons are unique to the lateral hypothalamic (LH) region, but project throughout the brain. These cell groups have been implicated in a variety of functions, including reward learning, responses to stimulants, and the modulation
Chanpreet Singh et al.
eLife, 4, e07000-e07000 (2015-09-17)
Pharmacological studies in mammals suggest that norepinephrine (NE) plays an important role in promoting arousal. However, the role of endogenous NE is unclear, with contradicting reports concerning the sleep phenotypes of mice lacking NE due to mutation of dopamine β-hydroxylase
Justin Liu et al.
Development (Cambridge, England), 142(6), 1113-1124 (2015-03-01)
Loss of neurons that express the neuropeptide hypocretin (Hcrt) has been implicated in narcolepsy, a debilitating disorder characterized by excessive daytime sleepiness and cataplexy. Cell replacement therapy, using Hcrt-expressing neurons generated in vitro, is a potentially useful therapeutic approach, but
Hannah Bruguier et al.
The Journal of comparative neurology, 528(17), 2956-2977 (2020-04-09)
The human claustrum, a major hub of widespread neocortical connections, is a thin, bilateral sheet of gray matter located between the insular cortex and the striatum. The subplate is a largely transient cortical structure that contains some of the earliest

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