AB120
Anti-Norepinephrine Antibody
serum, Chemicon®
Synonyme(s) :
Arterenol, Noradrenaline
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
serum
Type de produit anticorps
primary antibodies
Clone
polyclonal
Espèces réactives
human, rat
Fabricant/nom de marque
Chemicon®
Technique(s)
immunohistochemistry: suitable
Conditions d'expédition
dry ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... SLC6A2(6530)
Description générale
The chemical compound norepinephrine (NC(8)O(3)H(11), also known as noradrenaline, is a catecholamine that functions as both a neurotransmitter and a hormone. It is released from the adrenal glands and also by certain neurons. It affects parts of the human brain where attention and impulsivity are controlled. This compound affects the fight-or-flight response, activating the sympathetic nervous system to directly increase heart rate, release energy from fat and increase muscle readiness.
The host of physiological changes activated by a stressful event are unleashed in part by activation of a nucleus in the brain stem called the locus ceruleus. This nucleus is the origin of most norepinephrine pathways in the brain. Neurons using norepinephrine as their neurotransmitter project bilaterally from the locus ceruleus along distinct pathways to the cerebral cortex, limbic system, and the spinal cord, among other projections.
The host of physiological changes activated by a stressful event are unleashed in part by activation of a nucleus in the brain stem called the locus ceruleus. This nucleus is the origin of most norepinephrine pathways in the brain. Neurons using norepinephrine as their neurotransmitter project bilaterally from the locus ceruleus along distinct pathways to the cerebral cortex, limbic system, and the spinal cord, among other projections.
Spécificité
Noradrenaline: reactive with noradrenaline reacted with glutaraldehyde; glutaraldehyde required in fixation for reactivity; reactivity with free noradrenaline is very poor.
The cross-reactivities were determined using either ELISA or RIA techniques, at concentration/unconjugated or conjugated amino acid concentration at half displacement.
Compound Cross-reactivity
Noradrenaline-G-BSA 1.0
Octopamine-G-BSA 0.032
Dopamine-G-BSA 0.016
Adrenaline-G-BSA 0.006
Noradrenaline 0.0002
L-Dopa-G-BSA 0.0002
p-Tryamine-G-BSA 0.0002
*The antisera was also tested for specificity using the free-floating PAP technique on rat locus coeruleus.
Abbreviations:
(BSA)= Bovine serum albumin
G)= Glutaraldehyde
The cross-reactivities were determined using either ELISA or RIA techniques, at concentration/unconjugated or conjugated amino acid concentration at half displacement.
Compound Cross-reactivity
Noradrenaline-G-BSA 1.0
Octopamine-G-BSA 0.032
Dopamine-G-BSA 0.016
Adrenaline-G-BSA 0.006
Noradrenaline 0.0002
L-Dopa-G-BSA 0.0002
p-Tryamine-G-BSA 0.0002
*The antisera was also tested for specificity using the free-floating PAP technique on rat locus coeruleus.
Abbreviations:
(BSA)= Bovine serum albumin
G)= Glutaraldehyde
Immunogène
Noradrenaline-glutaraldehyde-BSA
Application
Anti-Norepinephrine Antibody is an antibody against Norepinephrine for use in IH.
Immunohistochemistry: 1:200-1:500 with enhanced detection. Glutaraldehyde fixation required for reactivity. Lightly fixed 4% PFA .2-5% glutaraldehyde fixed tissue works well; permeabilization with 0.1-.2% triton X-100 in block ONLY. Dilute antibody solutions in simple buffers without excess proteins or detergents.
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Hormones & Receptors
Hormones & Receptors
Forme physique
Liquid rabbit antiserum with 0.05% sodium azide.
Stockage et stabilité
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Informations légales
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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