8.55051

Biotin NovaTag^® resin

Novabiochem^®

• Synonyme(s) : N-Biotin-NÆ-Fmoc-ethylenediamine MPB-AM resin
• Code UNSPSC : 12352209

Propriétés

• Gamme de produits: NovaSyn^® TG; Novabiochem^®
• Forme: beads
• Capacité de réaction: reaction type: Fmoc solid-phase peptide synthesis
• Fabricant/nom de marque: Novabiochem^®
• Application(s): peptide synthesis
• Groupe fonctionnel: amine
• Température de stockage: 15-25°C

Description

Description générale

Biotin NovaTag resin is an ideal tool for the synthesis of peptides labeled with biotin. As the biotin moiety is incorporated into the linker, its use eliminates the problems associated with biotin-labeling of peptides, namely poor solubility and sluggish coupling kinetics of biotin and its derivatives. Following peptide assembly under standard Fmoc SPPS conditions, cleavage with TFA affords the peptide labeled with biotin. For a recent applications see ^[1,2].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

^[1] M. Carraz, et al. (2009) Chemistry & Biology, 16, 702.
^[2] S. Millward, et al. (2007) Chem. Biol., 2, 625.

Liaison

Replaces: 04-12-3901

Remarque sur l'analyse

Color (visual): white to light yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.35 - 0.65 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer metrix is copoly (styrene - 1% DVB), 100 - 200 mesh.

Informations légales

NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany

NOVATAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable