8.52104

Fmoc-Asp(OMpe)-OH

Novabiochem^®

• Synonyme(s) : Fmoc-Asp(OMpe)-OH, N-α-Fmoc-(O-3-methyl-pent-3-yl)aspartic acid
• Formule empirique (notation de Hill): C₂₅H₂₉NO₆
• Numéro CAS: 180675-08-5
• Poids moléculaire : 439.50
• Code UNSPSC : 12352209
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 200
• Gamme de produits: Novabiochem^®
• Forme: solid
• Capacité de réaction: reaction type: Fmoc solid-phase peptide synthesis
• Fabricant/nom de marque: Novabiochem^®
• Application(s): peptide synthesis
• Groupe fonctionnel: carboxylic acid
• Température de stockage: 15-25°C
• InChI: 1S/C25H29NO6/c1-4-25(3,5-2)32-22(27)14-21(23(28)29)26-24(30)31-15-20-18-12-8-6-10-16(18)17-11-7-9-13-19(17)20/h6-13,20-21H,4-5,14-15H2,1-3H3,(H,26,30)(H,28,29)/t21-/m0/s1
• Clé InChI: SYGKUYKLHYQKPL-NRFANRHFSA-N

Description

Description générale

An excellent derivative for minimizing aspartimide formation during Fmoc SPPS of Asp-containing peptides ^[1]. The bulky OMpe protecting group offers considerably more protection against the formation of aspartimide-related by-products than the commonly used OtBu group ^[1,2].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] A. Karlström (1996) Tetrahedron Lett., 37, 4243.
^[2] M. Mergler (2003) J. Pept. Sci., 9, 518.

Liaison

Replaces: 04-12-1259

Remarque sur l'analyse

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (DC (018A)): ≥ 98 %
Enantiomeric purity: ≥ 99.5 % (a/a)
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable