As reported in the 'DESCRIPTION' section of the product page, under 'Physical Form', the concentration is 100 mM or 5 mg/124 µl in DMSO.
662009
U0126
InSolution, ≥98%, A potent and specific inhibitor of MEK1 and MEK2
Synonyme(s) :
InSolution U0126
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About This Item
Formule empirique (notation de Hill):
C18H16N6S2 · 0.5C2H6O
Numéro CAS:
Poids moléculaire :
403.52
Numéro MDL:
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Niveau de qualité
Essai
≥98% (HPLC)
Forme
liquid
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
Conditions d'expédition
ambient
Température de stockage
−70°C
Chaîne SMILES
S(c2c(cccc2)N)\C(=C(\C(=C(\Sc1c(cccc1)N)/N)\C#N)/C#N)\N
InChI
1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
Clé InChI
DVEXZJFMOKTQEZ-JYFOCSDGSA-N
Description générale
A potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. Has very little effect on other kinases such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Reported to undergo rapid isomerization in DMSO and exist as an equilibrium mixture of (Z,Z), E,E) and (Z,E) isomers with minimal loss of activity over a period of 1 month.
Conditionnement
Packaged under inert gas
Avertissement
Toxicity: Irritant (B)
Forme physique
A 100 mM (5 mg/124 µl) solution of U0126 (Cat. No. 662005) in DMSO.
Reconstitution
Following initial thaw, aliquot into precooled vials, freeze immediately at (-70°C).
Autres remarques
Duncia, J.V., et al. 1998. Bioorg. Med. Chem. Lett.8, 2839.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Point d'éclair (°C)
87 °C - closed cup - (Dimethylsulfoxide)
Certificats d'analyse (COA)
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