557364
Roscovitine
InSolution, ≥95%, inhibitor of cyclin-dependent kinases (CDKs)
Synonyme(s) :
InSolution Roscovitine
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About This Item
Formule empirique (notation de Hill) :
C19H26N6O
Poids moléculaire :
354.45
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Niveau de qualité
Essai
≥95% (HPLC)
Forme
liquid
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
desiccated (hygroscopic)
protect from light
Conditions d'expédition
wet ice
Température de stockage
2-8°C
Description générale
A potent and selective inhibitor of cyclin-dependent kinases (Cdks). Exhibits greater inhibitory potency compared to olomoucine (Cat. No. 495620). Inhibits p34 Cdc2/cyclin B (IC50 = 650 nM), p33 Cdk2/cyclin A (IC50 = 700 nM), p33 Cdk2/cyclin E (IC50 = 700 nM), and p33 Cdk2/p35 (IC50 = 200 nM) by competing for the ATP binding domain of these kinases. Exhibits very low sensitivity towards related kinases, such as Erk1 and Erk2 (IC50 = 34 µM and 14 µM, respectively). Roscovitine does not significantly affect the activity of other protein kinases even at 100 µM and compared to olomoucine, roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle.
Actions biochimiques/physiologiques
Cell permeable: no
Primary Target
p34cdk1/cyclin B
p34cdk1/cyclin B
Product competes with ATP.
Reversible: yes
Target IC50: 650 nM, 700 nM, 700 nM, and 200 nM against p34cdk1/cyclin B, p33cdk2/cyclin A, p33cdk2/cyclin E, and p33cdk5/p35, respectively
Conditionnement
Packaged under inert gas
Avertissement
Toxicity: Irritant (B)
Forme physique
A 50 mM (5 mg/282 µl) solution of Roscovitine (Cat. No. 557360) in DMSO.
Reconstitution
Following initial use, aliquot and freeze (-20°C). Once opened, the DMSO aliquots are stable for up to 6 months at -20°C.
Autres remarques
Meijer, L. 1996. Trends Cell Biol.6, 393.
Rudolph, B., et al. 1996. EMBO J.15, 3053.
Rudolph, B., et al. 1996. EMBO J.15, 3053.
Informations légales
Sold under license of U.S. Patent 6,316,456.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Point d'éclair (°C)
87 °C - closed cup - (Dimethylsulfoxide)
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