171601

Amyloid Precursor Protein β-Secretase Inhibitor

The Amyloid Precursor Protein β-Secretase Inhibitor controls the biological activity of Amyloid Precursor Protein β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Synonyme(s) : Amyloid Precursor Protein β-Secretase Inhibitor, KTEETSEVN(stat)VAEF
• Formule empirique (notation de Hill): C₇₃H₁₁₈N₁₆O₂₇
• Poids moléculaire : 1651.81
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: lyophilized
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Solubilité: aqueous buffer, pH 7.5: 1 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

A potent inhibitor of the amyloid precursor protein (APP) β-secretase (IC₅₀ = 30 nM).

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
APP

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 30 nM against amyloid precursor protein (APP) β-secretase

Avertissement

Toxicity: Standard Handling (A)

Séquence

H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Stat-Val-Ala-Glu-Phe-OH [Stat = (3S,4S)-Statine]

Forme physique

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Sinha, S., et al. 1999. Nature 402, 537.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable