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07-909

Sigma-Aldrich

Anti-phospho-Src (Tyr418) Antibody

Upstate®, from rabbit

Synonyme(s) :

c-Src, p60-Src Src kinase

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

chicken, human, mouse

Fabricant/nom de marque

Upstate®

Technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

Isotype

IgG

Numéro d'accès NCBI

NM_005417.3
NM_198291.1

Numéro d'accès UniProt

P12931

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

phosphorylation (pTyr418)

Informations sur le gène

human ... SRC(6714)

Spécificité

Predicted to cross-react with Rat and Frog (100% homologous) based on sequence homology.
Recognizes Src phosphorylated on Tyrosine residue 418.

Immunogène

Peptide corresponding to amino acid region encompassing the human, mouse, rat, chicken, and frog phospho-Src (Tyr418)

Application

Anti-phospho-Src (Tyr418) Antibody detects level of phospho-Src (Tyr418) & has been published & validated for use in IC, IH & WB.
Immunoblot Analysis: 1:1000 dilutions of this lot detected phospho-Src (Tyr418) in RIPA lysate of Src transfected CEF cells.
Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling

Qualité

Routinely evaluated by immunoblot.

Description de la cible

60 kDa

Forme physique

Affinity Purified rabbit polyclonal IgG in PBS (without Mg2+ and Ca2+), pH 7.3 containing 0.5 mg/mL BSA (IgG, protease free) and 0.025% sodium azide and 50% glycerol.
ImmunoAffinity Purified

Stockage et stabilité

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Remarque sur l'analyse

Control
Chick embryo fibroblast (CEF) cells expressing human wild-type Src protein

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Aida Habibovic et al.
JCI insight, 1(18), e88811-e88811 (2016-11-05)
Chronic inflammation with mucous metaplasia and airway remodeling are hallmarks of allergic asthma, and these outcomes have been associated with enhanced expression and activation of EGFR signaling. Here, we demonstrate enhanced expression of EGFR ligands such as amphiregulin as well
Functional stability of a mixed microbial consortium producing PHA from waste carbon sources.
Erik R Coats,Frank J Loge,William A Smith,David N Thompson,Michael P Wolcott
Applied Biochemistry and Biotechnology null
Src: regulation, role in human carcinogenesis and pharmacological inhibitors.
Tsygankov, A Y and Shore, S K
Current Pharmaceutical Design, 10, 1745-1756 (2004)
c-Src and cooperating partners in human cancer
Ishizawar, Rumey and Parsons, Sarah J
Cancer Cell, 6, 209-214 (2004)
Shinkyu Choi et al.
Antioxidants & redox signaling, 30(4), 505-519 (2018-01-18)
Altered redox state has been related to the development of normal pregnancy (NP) and preeclampsia (PE). Endothelial KCa2.3 and KCa3.1 (KCas) play an important role in vasodilation, and KCas levels are affected by oxidative stress. We investigated the mechanisms of
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