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Key Documents

03-0207-00

Millipore

SMC® Human PD-1 High Sensitivity Immunoassay Kit

Synonyme(s) :

PD-1 Single Molecule Counting kit, PD-1 ultra-sensitive immunoassay, PD-1 immunoassay kit, Programmed cell death protein 1 kit, PD-1 kit

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About This Item

Code UNSPSC :
12161503
Nomenclature NACRES :
NA.47

Espèces réactives

human

Niveau de qualité

Paramètres

50 μL sample volume (diluted 2-fold in standard diluent)

assay range

intra-assay cv: ≤5%
(n=15)

linearity: 80-117%
(Plasma)

linearity: 91-135%
(Serum)

recovery range: 53-100%
(Plasma)

recovery range: 80-109%
(Serum)

sensitivity: 1.74 pg/mL
standard curve range: 0.87-3,000 pg/mL
inter-assay cv: ≤14%
(n=15)

Technique(s)

single molecule counting: suitable

Entrée

sample type plasma (K2 EDTA)
sample type serum

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Description générale

Programmed cell death protein 1 (PD-1), CD279, is a type I membrane protein found in T cells, B cells, and macrophages that binds Programmed cell death ligand 1 and 2 (PD-L1 and PD-L2). PD-1 is found in both soluble and insoluble forms. PD-1 regulates the body’s immune response through a variety of pathways, down-regulating immune system activity and suppressing T-cell inflammatory activity. PD-1 has been implicated as playing a role in cancers, autoimmune diseases, the immune response to viruses, and in immunological pathways related to brain repair. As an immune checkpoint, PD-1 promotes apoptosis of antigen-specific T-cells in lymph nodes and reduces apoptosis in regulatory T-cells. Blockers of the PD-1 pathway have been approved as cancer therapeutics.

Research Category: Cancer
Research Sub-Category: Immuno-Oncology

Spécificité

This assay was tested for cross-reactivity with PD-L1. No cross-reactivity was detected with this analyte.

Application

Used for ultrasensitivite quantification of Human PD-1 in human serum and plasma.

Caractéristiques et avantages

This SMC® kit features:
  • Accurate and reproducible performance on the state-of-the-art SMCxPRO® ultrasensitive immunoassay system.
  • Compatiblity with automated liquid handling

Informations légales

SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictogrammes

Health hazardExclamation mark

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation

Organes cibles

Respiratory Tract

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects


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Contenu apparenté

Guide on selecting immunoassay platforms including multiplex vs. singleplex assays, instruments, software, and services.

Guide on selecting immunoassay platforms including multiplex vs. singleplex assays, instruments, software, and services.

Guide on selecting immunoassay platforms including multiplex vs. singleplex assays, instruments, software, and services.

Guide on selecting immunoassay platforms including multiplex vs. singleplex assays, instruments, software, and services.

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