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M-020

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S(+)-Methamphetamine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Synonyme(s) :

dextro-Methamphetamine

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About This Item

Formule empirique (notation de Hill):
C10H15N
Numéro CAS:
537-46-2
Poids moléculaire :
149.23
Numéro MDL:
MFCD00079140
Code UNSPSC :
41116107
ID de substance PubChem :
329817739
Nomenclature NACRES :
NA.24

Qualité

certified reference material

Forme

liquid

Caractéristiques

Snap-N-Spike®/Snap-N-Shoot®

Conditionnement

ampule of 1 mL

Fabricant/nom de marque

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal)

Concentration

1.0 mg/mL in methanol

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Application(s)

forensics and toxicology

Format

single component solution

Température de stockage

2-8°C

Chaîne SMILES 

CN[C@@H](C)Cc1ccccc1

InChI

1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3/t9-/m0/s1

Clé InChI

MYWUZJCMWCOHBA-VIFPVBQESA-N

Informations sur le gène

human ... SLC6A2(6530) , SLC6A3(6531) , SLC6A4(6532)

Catégories apparentées

Description générale

Methamphetamine is a psychostimulant drug of the phenethylamine and amphetamine classes. Known by the street names "meth," "ice," and "glass", this Snap-N-Spike® reference solution is applicable for use in LC/MS or GC/MS applications including clinical toxicology, sports testing, forensic analysis, or urine drug testing. The dextrorotatory isomer of methamphetamine is sold under the trade name Desoxyn® for treatment of ADHD and obesity.

Application


  • Pharmacokinetic Studies of S(+)-Methamphetamine: A comprehensive study assessing the pharmacokinetic profile of S(+)-Methamphetamine highlighted its rapid absorption and metabolism, offering critical insights into its therapeutic potential and challenges in drug abuse scenarios. This research aids in optimizing dosing regimens and understanding the drug′s behavior in biological systems, essential for both clinical applications and forensic investigations (Rushton et al., 2024).

  • Pharmaceutical Applications of S(+)-Methamphetamine: Research on S(+)-Methamphetamine′s role in neurochemical processes explored its effects on neurotransmitter systems, particularly focusing on its potential therapeutic applications for attention deficit hyperactivity disorder (ADHD) and weight loss. Studies like these inform drug design and repurposing strategies, helping to mitigate abuse risks while harnessing pharmacological benefits (Pardo et al., 2024).

  • Drug Metabolism and Enantiomeric Analysis: Investigations into the metabolism of S(+)-Methamphetamine have provided detailed insights into its biotransformation pathways, crucial for developing antidotes and treatment strategies for overdose cases. This research also enhances the understanding of enantiomeric differences in drug activity, supporting the development of more targeted and effective therapeutic agents (Liut et al., 2024).

  • Clinical Trials and Neurological Research: Systematic reviews of clinical trials involving S(+)-Methamphetamine have elucidated its complex pharmacodynamics and associated behavioral effects. This information is vital for neuroscientists and pharmacologists working to develop safer and more effective CNS stimulants with fewer side effects and lower abuse potential (Barkholtz et al., 2023).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Desoxyn is a registered trademark of Abbott Laboratories Corp.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

M-023

(±)-Methamphetamine-D5 solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-090

(±)-Methamphetamine-D9 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-091

(±)-Methamphetamine-D9 solution, 1 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

A-050

Amine Mixture-6 solution, 250 μg/mL each component in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-025

Methamphetamine/Cocaine/Heroin solution, 250 μg/mL each component in acetonitrile, ampule of 1.0 mL, certified reference material, Cerilliant®

M-004

(±)-Methamphetamine-D5 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-009

(±)-Methamphetamine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-016

(±)-Methamphetamine-D8 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-022

(±)-Methamphetamine solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-024

R(-)-Methamphetamine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-034

(±)-Methamphetamine-D8 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-059

(±)-Methamphetamine-D11 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-060

(±)-Methamphetamine-D11 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-092

(±)-Methamphetamine-D14 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-093

(±)-Methamphetamine-D14 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-259

(±)-Methamphetamine-13C6 hydrochloride solution, 100 μg/mL in methanol (as free base), certified reference material, ampule of 1 mL, Cerilliant®

Pictogrammes

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organes cibles

Eyes

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

49.5 °F - closed cup

Point d'éclair (°C)

9.7 °C - closed cup

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Brett A Dolezal et al.
Journal of addiction medicine, 7(2), 122-128 (2013-04-05)
Physical exercise has been shown to benefit diverse medical and behavioral conditions. This study assesses the feasibility and efficacy of an 8-week endurance and resistance training program on fitness measures in individuals undergoing residential treatment for methamphetamine (MA) dependence. A
Glen R Hanson et al.
The Journal of pharmacology and experimental therapeutics, 346(2), 173-181 (2013-05-21)
Because of persistent social problems caused by methamphetamine (METH), new therapeutic strategies need to be developed. Thus, we investigated the response of central nervous system neurotensin (NT) systems to METH self-administration (SA) and their interaction with basal ganglia dopamine (DA)
Jeffrey T Parsons et al.
AIDS and behavior, 17(4), 1478-1487 (2013-04-05)
Methamphetamine use is associated with HIV infection, especially among gay and bisexual men. Methamphetamine use contributes to disease progression both directly, by increasing viral load and damaging the immune system, and indirectly, by decreasing medication adherence. Research examining the association
Amy J Eshleman et al.
Biochemical pharmacology, 85(12), 1803-1815 (2013-04-16)
The use of synthetic methcathinones, components of "bath salts," is a world-wide health concern. These compounds, structurally similar to methamphetamine (METH) and 3,4-methylendioxymethamphetamine (MDMA), cause tachycardia, hallucinations and psychosis. We hypothesized that these potentially neurotoxic and abused compounds display differences
Diane M Herbeck et al.
Journal of psychoactive drugs, 45(2), 132-140 (2013-08-03)
This study examines health and legal problems associated with use of commonly reported substances and combinations of substances in a sample of adults with long histories of methamphetamine (meth) use. Data are from a 2009-11 eight-year follow-up interview in an
Afficher tous les articles scientifiques apparentés

Protocoles

Accurate Biological Testing for Amphetamine and Methamphetamine Abuse Using Chiral HPLC and MS Detection

Optimized sample prep and chiral chromatography methods for the LC/MS analysis of these drug enantiomers in urine

Biological Testing for Amphetamine and Methamphetamine Abuse

In this study, optimized methods are presented for sample preparation and chiral chromatography for the LC/MS analysis of amphetamine and methamphetamine enantiomers in urine.

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