870600P
Avanti
PAzePC
Avanti Research™ - A Croda Brand 870600P, powder
Synonyme(s) :
1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine
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About This Item
Formule empirique (notation de Hill):
C33H64NO10P
Numéro CAS:
Poids moléculaire :
665.84
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25
Produits recommandés
Forme
powder
Conditionnement
pkg of 1 × 1 mg (870600P-1mg)
Fabricant/nom de marque
Avanti Research™ - A Croda Brand 870600P
Conditions d'expédition
dry ice
Température de stockage
−20°C
Chaîne SMILES
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCC(O)=O)=O)COC(CCCCCCCCCCCCCCC)=O)=O
Description générale
1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PAzePC) structure contains an anionic carboxyl group at the end of the short, oxidized acyl chain.
Application
1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PazePC) may be used as an oxidized lipid dopant in liposomes for examining the link between the permeation of H2O2 and the structure of lipid membranes. It may also be used as lysosomal phospholipase A2 substrate in the study of structural basis for Zn2+ mediated inhibition of lysosomal phospholipase A2.
Actions biochimiques/physiologiques
1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PazePC) is a stable lipid oxidation product. It serves as an inter-H2O2 permeation promoter. It is the most common drug target for antipsychotic and antimicrobial agents in cells under oxidative stress at inflammatory sites.
Conditionnement
5 mL Amber Glass Screw Cap Vial (870600P-1mg)
Informations légales
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Souvent commandé avec ce produit
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Renee A Bouley et al.
Biochemistry, 58(13), 1709-1717 (2019-03-05)
Lysosomal phospholipase A2 (LPLA2/PLA2G15) is a key enzyme involved in lipid homeostasis and is characterized by both phospholipase A2 and transacylase activity and by an acidic pH optimum. Divalent cations such as Ca2+ and Mg2+ have previously been shown to
Himanshu Khandelia et al.
Biophysical journal, 96(7), 2734-2743 (2009-04-08)
In oxidative environments, biomembranes contain oxidized lipids with short, polar acyl chains. Two stable lipid oxidation products are PoxnoPC and PazePC. PoxnoPC has a carbonyl group, and PazePC has an anionic carboxyl group pendant at the end of the short
Yuya Ouchi et al.
Scientific reports, 9(1), 12497-12497 (2019-08-31)
H2O2 permeation through a cell membrane significantly affects living organisms, and permeation is controlled by the physico-chemical nature of lipids and other membrane components. We investigated the molecular relationship between H2O2 permeation and lipid membrane structure using three oxidized lipids.
Mooud Amirkavei et al.
Biochimica et biophysica acta, 1858(2), 264-273 (2015-12-15)
In order to obtain molecular level insight into the biophysics of the apoptosis promoting phospholipid 1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PazePC) we studied its partitioning into different lipid phases by isothermal titration calorimetry (ITC). To aid the interpretation of these data for PazePC, we
Cintia Kawai et al.
The journal of physical chemistry. B, 118(41), 11863-11872 (2014-09-24)
Fluorescence quenching of lipid-bound pyrene was used to assess the binding of cytochrome c (cyt c) to liposomes that mimic the inner mitochondrial membrane (IMM) POPC/DOPE/TOCL, with the conditions that it did or did not contain oxidized phosphatidylcholine molecules, i.e.
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