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700072P

Avanti

zymosterol-d5

Avanti Research - A Croda Brand

Synonyme(s) :

(2,2,3,4,4-D5)-5α-cholesta-8,24-dien-3β-ol

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About This Item

Formule empirique (notation de Hill):
C27H39D5O
Numéro CAS:
Poids moléculaire :
389.67
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Description

(2,2,3,4,4-d5)-zymosterol

Pureté

>99% (TLC)

Forme

powder

Conditionnement

pkg of 1 × 1 mg (700072P-1mg)

Fabricant/nom de marque

Avanti Research - A Croda Brand

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

C[C@]12CCC([C@](CC([2H])([2H])[C@@](O)([2H])C3([2H])[2H])(C)C3CC4)=C4[C@]1([H])CC[C@]2([H])[C@]([H])(C)CCC=C(C)C

Description générale

Zymosterol-d5 is the deuterated form of zymosterol. Zymosterol is a precursor of cholesterol and the synthesis events occur in rough endoplasmic reticulum.

Application

Zymosterol-d5 has been used as a standard in liquid chromatography–mass spectrometry (LC-MS) for quantification of sterols from human plasma samples.

Actions biochimiques/physiologiques

Zymosterol is a substrate for 24-dehydrocholesterol reductase. It acts as a methyl acceptor and exists as fatty acid ester aerobically-grown yeast cells.

Conditionnement

5 mL Amber Glass Screw Cap Vial (700072P-1mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

No data available

Point d'éclair (°C)

No data available


Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Jeffrey G McDonald et al.
Journal of lipid research, 53(7), 1399-1409 (2012-04-21)
We describe the development of a method for the extraction and analysis of 62 sterols, oxysterols, and secosteroids from human plasma using a combination of HPLC-MS and GC-MS. Deuterated standards are added to 200 μl of human plasma. Bulk lipids
N Ariga et al.
Journal of biochemistry, 83(4), 1109-1116 (1978-04-01)
In order to identify the methyl acceptor for the methylation of sterol side-chains in ergosterol biosynthesis, Saccharomyces cerevisiae (wild type) was grown in the presence and absence of ethionine which was expected to be an inhibitor of the methylation. Gas-liquid
Y Lange et al.
The Journal of biological chemistry, 266(32), 21439-21443 (1991-11-15)
Where examined, cholesterol is synthesized in the endoplasmic reticulum; however, its precursor, zymosterol, is found mostly in the plasma membrane. The novel implication of these disparate findings is that zymosterol circulates within the cell. In tracing its movements, we have
Natalia Mast et al.
PloS one, 12(10), e0187168-e0187168 (2017-10-27)
Cytochrome P450 46A1 (CYP46A1) converts cholesterol to 24-hydroxycholesterol and thereby controls the major pathways of cholesterol removal from the brain. Cyp46a1-/- mice have a reduction in the rate of cholesterol biosynthesis in the brain and significant impairments to memory and

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