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Merck
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Key Documents

922412

Sigma-Aldrich

EncapGel™ sustained release hydrogel for drug delivery

Synonyme(s) :

Drug delivery, Hydrogel, LT-GEL, TGelBio

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About This Item

Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23

Forme

powder

Niveau de qualité

100

Impuretés

≤0.125 EU/mg Endotoxin

Couleur

white to off-white

Catégories apparentées

Application

EncapGel™ sustained release drug delivery hydrogel can be used for the encapsulation and delivery of drug or cells. The solution gels rapidly at 20 °C to 36 °C. Reverse thermal property of this hydrogel allows the percutaneous injection and immediate gelation in the body. The hydrogel matrix allows the spatial control of desired therapeutic agent in the vicinity of the target area. This hydrogel matrix is biodegraded completely within 3 days in-vivo, which allows the sustained release of the therapeutic agent to the targeted area. It is a research use only product to test the safety and efficacy of various therapeutic agents, such as drugs, small bioactive molecules, proteins, exosomes, targeted administration of micro- and nano-particles encapsulating therapeutic agents, or cellular-based therapeutics. This product is in a lyophilized powder form, and each vial can make 5 mL hydrogel.

Conditionnement

1.025 g in a glass vial

Informations légales

ENCAPGEL is a trademark of Sigma-Aldrich Co. LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Certificats d'analyse (COA)

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Keun Sang Oh et al.
International journal of pharmaceutics, 558, 225-230 (2019-01-18)
Postoperative pain is a common form of acute pain that has been treated commonly by local anesthetics through regional nerve blocking. In this study, a series of experiments were conducted using rats to investigate the pharmacokinetic, distribution, and efficacy of
Jin Whan Lee et al.
Journal of biomedical materials research. Part A, 92(1), 378-385 (2009-02-05)
Possible solution to the long-term control of the low back pain (LBP) would be by using an injectable pain drug carrier that can be delivered locally. The drug can be released in a controlled manner. It is also allowed to
Yusung Kim et al.
International journal of radiation oncology, biology, physics, 88(5), 1142-1147 (2014-02-06)
To propose a novel radiation therapy (RT) delivery modality: locally targeted delivery of micron-size RT sources by using temperature-sensitive hydrogel (RT-GEL) as an injectable vehicle. Hydrogel is a water-like liquid at room temperature but gels at body temperature. Two US
Dongrim Seol et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 101(8), 1508-1515 (2014-03-05)
We recently introduced a novel pluronic F127 and hyaluronic acid-based hydrogel (HG) designed to deliver a broad range of therapeutics. The reverse-thermal responsive HG exhibits physical properties that seem to be ideal for the local delivery of drug- and cell-based

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