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286044

Sigma-Aldrich

Harmine

98%

Synonyme(s) :

7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole

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About This Item

Formule empirique (notation de Hill):
C13H12N2O
Numéro CAS:
442-51-3
Poids moléculaire :
212.25
Numéro Beilstein :
178813
Numéro CE :
207-131-4
Numéro MDL:
MFCD00004958
Code UNSPSC :
12352100
ID de substance PubChem :
24857229
Nomenclature NACRES :
NA.22

Pureté

98%

Pf

262-264 °C (lit.)

Chaîne SMILES 

CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3

InChI

1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3

Clé InChI

BXNJHAXVSOCGBA-UHFFFAOYSA-N

Informations sur le gène

human ... CDC2(983) , CYP2D6(1565)

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Description générale

The combination index (CI, serves as a quantitative indicator of pharmacological interactions) for harmaline/harmine and methylene blue/harmine was studied.

Application

Harmine was used as a donor in the fluorescence resonance energy transfer (FRET) study between harmine and silver nanoparticles (AgNPs).

Actions biochimiques/physiologiques

Central nervous system stimulant.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Katie L Uhl et al.
Cancer cell international, 18, 82-82 (2018-07-07)
Neuroblastoma (NB) is an early childhood malignancy that arises from the developing sympathetic nervous system. Harmine is a tricyclic β-carboline alkaloid isolated from the harmal plant that exhibits both cytostatic and cytotoxic effects. Harmine is capable of blocking the activities
Michael F Santillo et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(3), 403-410 (2014-01-01)
Interactions among monoamine oxidase (MAO) inhibitors in drugs, botanicals, and dietary supplements may lead to unpredictable neurochemical dysfunction due to excessive inhibition or therapeutic invalidation. Often recombinant MAO or brain tissue homogenates have been used to evaluate MAO inhibitors such
Mansour Debdab et al.
Journal of medicinal chemistry, 54(12), 4172-4186 (2011-05-28)
We here report on the synthesis, optimization, and biological characterization of leucettines, a family of kinase inhibitors derived from the marine sponge leucettamine B. Stepwise synthesis of analogues starting from the natural structure, guided by activity testing on eight purified
Mohammad Amjadi et al.
Luminescence : the journal of biological and chemical luminescence, 29(6), 689-694 (2013-11-30)
This article reports on a novel fluorescence resonance energy transfer (FRET) system between harmine and silver nanoparticles (AgNPs), in which harmine acts as the donor and AgNPs act as the acceptor. As a result of FRET, harmine fluorescence is quenched
Vikalp Vishwakarma et al.
Scientific reports, 8(1), 12163-12163 (2018-08-17)
Head and neck squamous cell carcinoma (HNSCC) is associated with low survival, and the current aggressive therapies result in high morbidity. Nutraceuticals are dietary compounds with few side effects. However, limited antitumor efficacy has restricted their application for cancer therapy.
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