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12072

Sigma-Aldrich

Benzamidine

≥95.0%

Synonyme(s) :

Benzenylamidine, Phenylamidine

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About This Item

Formule linéaire :
C6H5C(=NH)NH2
Numéro CAS:
618-39-3
Poids moléculaire :
120.15
Beilstein:
606020
Numéro CE :
210-546-3
Numéro MDL:
MFCD00042826
Code UNSPSC :
12352100
ID de substance PubChem :
57646968
Nomenclature NACRES :
NA.22
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Niveau de qualité

200

Essai

≥95.0%

Forme

powder or crystals

Groupe fonctionnel

amine
phenyl

Chaîne SMILES 

NC(=N)c1ccccc1

InChI

1S/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9)

Clé InChI

PXXJHWLDUBFPOL-UHFFFAOYSA-N

Informations sur le gène

human ... F10(2159) , F2(2147) , PLAT(5327) , PLAU(5328) , PLG(5340) , PRSS1(5644)

Catégories apparentées

Application

Benzamidine was used in the preparation of heparan sulfate-rich proteoglycan from mouse mammary epithelial cells[1]. It has been used to prevent enzymatic degradation during the purification procedure of bovine factor XII (Hageman factor)[2].

Actions biochimiques/physiologiques

Benzamidine is an inhibitor of plasmin and has been used in the radioimmunoassay of glucagon in human plasma[3]. It prevents the destruction of Thyrotropin-releasing hormone (TRH) added to whole blood in vitro before radioimmunoassay of TRH[4].

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
BCCJ0849
BCCB9118
BCBT9196
BCBL7181V
BCBF3350V

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Purification and characterization of bovine coagulation factor XII (Hageman factor).
H Claeys et al.
European journal of biochemistry, 87(1), 69-74 (1978-06-01)
Hung-Wei Chang et al.
PLoS pathogens, 15(6), e1007826-e1007826 (2019-06-21)
Vaccinia mature virus requires A26 envelope protein to mediate acid-dependent endocytosis into HeLa cells in which we hypothesized that A26 protein functions as an acid-sensitive membrane fusion suppressor. Here, we provide evidence showing that N-terminal domain (aa1-75) of A26 protein
Use of benzamidine as a proteolytic inhibitor in the radioimmunoassay of glucagon in plasma.
J W Ensinck et al.
The Journal of clinical endocrinology and metabolism, 35(3), 463-467 (1972-09-01)
Ana L Roa-Espitia et al.
Biology open, 5(9), 1189-1199 (2016-07-13)
Several focal adhesion proteins are known to cooperate with integrins to link the extracellular matrix to the actin cytoskeleton; as a result, many intracellular signaling pathways are activated and several focal adhesion complexes are formed. However, how these proteins function
Karina Smorodinsky-Atias et al.
Molecular biology of the cell, 27(6), 1026-1039 (2015-12-15)
The receptor-tyrosine kinase (RTK)/Ras/Raf pathway is an essential cascade for mediating growth factor signaling. It is abnormally overactive in almost all human cancers. The downstream targets of the pathway are members of the extracellular regulated kinases (Erk1/2) family, suggesting that
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Questions

1–6 of 6 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. The buffer preparation protocol calls for benzamidine. Should I use the free base or the hydrochloride hydrate salt?

    1 answer

    1. It is possible that either the benzamidine or the benzamidine hydrochloride hydrate could work for your application. The major difference will be that the benzamidine hydrochloride hydrate (Product No. B6506) is expected to dissolve easier in aqueous solutions. Neither Product 12072 nor the salt Product B5606 is molecular biology, cell culture or biotechnology certified, so their performance once dissolved is likely to be similar.

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  4. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  5. What solvents can be used to dissolve Benzamidine, Product 12072?

    1 answer

    1. Based on our experience with this compound in quality control, we would expect it to be soluble in methanol (0.5g in 10mL of methanol).

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  6. What is the solution stability of Benzamidine, Product 12072?

    1 answer

    1. Sigma-Aldrich does not perform formal solution stability testing on this material; however, it is expected to be sensitive to oxidation. It is recommended to prepare solutions fresh for each use.

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