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1269243

USP

Famotidine Related Compound D

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

3-{{{2-[(Diaminomethylene)amino]thiazol-4-yl}methyl}sulphanyl}propanamide, 3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]propanamide

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About This Item

Empirical Formula (Hill Notation):
C8H13N5OS2
CAS Number:
Molecular Weight:
259.35
UNSPSC Code:
41116107
NACRES:
NA.24

biological source

synthetic

grade

pharmaceutical primary standard

Agency

USP

API family

famotidine

form

powder

packaging

pkg of 25 mg

manufacturer/tradename

USP

storage condition

protect from light

color

white

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C8H13N5OS2/c9-7(14)1-2-15-3-6-4-16-8(13-6)11-5-12-10/h4-5H,1-3,10H2,(H2,9,14)(H,11,12,13)

InChI key

ASHSLSDRNNWQKI-UHFFFAOYSA-N

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General description

Famotidine Related Compound D (Famotidine Impurity D) is an impurity of famotidine, which is a hydrophilic, cationic, histamine H2 receptor antagonist drug that effectively inhibits gastric acid secretion in humans.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Famotidine Related Compound D USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monograph such as Famotidine

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Development and validation of chromatographic methods for simultaneous determination of ibuprofen and famotidine in presence of related substances in pharmaceutical formulations
Elzanfaly ES, et al.
Acta Chimica Slovenica, 62(1) (2014)
Famotidine
Pharmacopeia, US
United States Pharmacopeia, 39(1)(1-2), 1815-1815 (2020)
Photoaffinity labeling of the anionic sites in Caco-2 cells mediating saturable transport of hydrophilic cations ranitidine and famotidine
Bourdet DL, et al.
Journal of medicinal chemistry, 47(11) (2004)
Stability indicating method for famotidine in pharmaceuticals using porous graphitic carbon column
Helali N and Monser L
Journal of Separation Science, 31(2) (2008)
RP-HPLC determination of famotidine and its potential impurities in pharmaceuticals
Helali N, et al.
Chromatographia, 60(7-8) (2004)

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