80198

Methoxatin disodium salt

≥97.0% (HPLC)

• Synonym(s): PQQ, Pyrrolo-quinoline-quinone disodium salt
• Empirical Formula (Hill Notation): C₁₄H₄N₂Na₂O₈
• CAS Number: 122628-50-6
• Molecular Weight: 374.17
• MDL number: MFCD00151711
• UNSPSC Code: 12352005
• PubChem Substance ID: 329768729
• NACRES: NA.79

Properties

• biological source: fermentation/recombinant
• Quality Level: 100
• Assay: ≥97.0% (HPLC)
• form: powder
• color: red-brown to deep orange; red-brown to deep red-brown
• storage temp.: 2-8°C
• SMILES string: OC(=O)c1cc(nc2C(=O)C(=O)c3cc([nH]c3-c12)C(=O)O[Na])C(=O)O[Na]
• InChI: 1S/C14H6N2O8.2Na/c17-10-4-2-6(14(23)24)15-8(4)7-3(12(19)20)1-5(13(21)22)16-9(7)11(10)18;;/h1-2,15H,(H,19,20)(H,21,22)(H,23,24);;/q;2*+1/p-2
• InChI key: UFVBOGYDCJNLPM-UHFFFAOYSA-L

Description

General description

Methoxatin/pyrroloquinoline quinone (PQQ) is mostly seen in plants, few bacteria and single cell eukaryotes, like yeast. It is mainly obtained from methylotrophic bacteria. PQQ may also present in the tissues of mammals.

Application

• Safety assessment of a novel, dietary pyrroloquinoline quinone disodium salt (mnemoPQQ): This study investigates the safety profile of Methoxatin disodium salt, which has implications for its application in assay development for clinical and diagnostic purposes. Specifically, it addresses the compound′s use in dietary supplements and potential crossover into clinical assays where safety and toxicity are paramount (Shiojima et al., 2022).

Biochem/physiol Actions

In bacteria, pyrroloquinoline quinone (PQQ) is used as a redox cycling cofactor. It acts as a cofactor (prosthetic group) for enzyme-catalyzed redox reactions of glucose and methanol dehydrogenase(s). PQQ is used in liposomes to establish a simple homogeneous assay for the detection of membrane permeabilization by antimicrobial peptides and synthetic copolymers. In bovine plasma amine oxidase, methoxatin may acts as the cofactor.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves