N5535

Niacinamide

meets USP testing specifications

• Synonym(s): Nicotinamide, Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B₃, Vitamin PP
• Empirical Formula (Hill Notation): C₆H₆N₂O
• CAS Number: 98-92-0
• Molecular Weight: 122.12
• Beilstein: 383619
• EC Number: 202-713-4
• MDL number: MFCD00006395
• UNSPSC Code: 12352205
• PubChem Substance ID: 24897740
• NACRES: NA.21

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• Agency: USP/NF; meets USP testing specifications
• Assay: 98.5-101.5% dry basis
• form: crystals
• color: white
• mp: 128-131 °C (lit.)
• application(s): pharmaceutical (small molecule)
• SMILES string: NC(=O)c1cccnc1
• InChI: 1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
• InChI key: DFPAKSUCGFBDDF-UHFFFAOYSA-N
• Gene Information: human ... PARP1(142) , SIRT2(22933)

Description

General description

Niacinamide, also known as 3-pyridinecarboxamide, is a water soluble vitamin. It is widely present in plants, animal food and cosmetics.

Application

Niacinamide has been used:

• as a component of islet maturation culture media
• to induce differentiation of insulin secreting cells
• to compare its preclinical effectiveness with that of progesterone

Biochem/physiol Actions

Niacinamide is a primary precursor of nicotinamide adenine dinucleotide (NAD⁺), which is an important coenzyme in adenosine triphosphate (ATP) production. Nicotinamide deficiency is associated with pellagra.

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319
• Precautionary Statements: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): 302.0 °F - closed cup
• Flash Point(C): 150 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves