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Key Documents

COA/COQ

07-234

Anti-REA Antibody

Name: Anti-REA Antibody
Brand: MM

Upstate^®, from rabbit

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

rabbit

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, rat, mouse

manufacturer/tradename

Upstate^®

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_007273

UniProt accession no.

Q99623

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PHB2(11331)

Related Categories

Antibodies - Primary, Secondary & Recombinant Monoclonal

Specificity

REA

Immunogen

His6-tagged fusion protein corresponding to amino acid residues 88-299 of mouse REA-1/BAP-37/prohibitin-related protein

Application

Detect REA with Anti-REA Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP, WB, ICC.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Transcription Factors

Quality

routinely evaluated by immunoblot on 3T3 nuclear extract

Target description

37kDa

Physical form

200 μg of protein A purified rabbit IgG in 200 μL of 0.07 M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide and 30% glycerol.

Format: Purified

Protein A chromatography

Storage and Stability

2 years at -20°C

Analysis Note

Control
3T3 nuclear extract

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway.

Shufeng Liu et al.

EBioMedicine, 2(11), 1600-1606 (2016-02-13)

Identification of novel drug targets and affordable therapeutic agents remains a high priority in the fight against chronic hepatitis C virus (HCV) infection. Here, we report that the cellular proteins prohibitin 1 (PHB1) and 2 (PHB2) are pan-genotypic HCV entry

NOXA upregulation by the prohibitin-binding compound fluorizoline is transcriptionally regulated by integrated stress response-induced ATF3 and ATF4.

Sonia Núñez-Vázquez et al.

The FEBS journal, 288(4), 1271-1285 (2020-07-11)

Fluorizoline is a new synthetic molecule that induces p53-independent apoptosis, in several tumor cell lines and in primary leukemia cells, by selectively targeting prohibitins (PHBs). In this study, we describe how fluorizoline induces BCL-2 homology 3-only protein NOXA, without modulating

The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells.

Sonia Núñez-Vázquez et al.

Oncogenesis, 10(9), 64-64 (2021-09-29)

Fluorizoline is a prohibitin-binding compound that triggers apoptosis in several cell lines from murine and human origin, as well as in primary cells from hematologic malignancies by inducing the integrated stress response and ER stress. Recently, it was described that

Repressor of estrogen receptor activity (REA) is essential for mammary gland morphogenesis and functional activities: studies in conditional knockout mice.

Sunghee Park et al.

Endocrinology, 152(11), 4336-4349 (2011-08-25)

Estrogen receptor (ER) is a key regulator of mammary gland development and is also implicated in breast tumorigenesis. Because ER-mediated activities depend critically on coregulator partner proteins, we have investigated the consequences of reduction or loss of function of the

Prohibitins are involved in protease-activated receptor 1-mediated platelet aggregation.

Y Zhang,Y Wang,Y Xiang,W Lee

Journal of Thrombosis and Haemostasis null

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