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289396

Sigma-Aldrich

Hydroxyapatite

reagent grade, powder, synthetic

Synonym(s):

Calcium phosphate tribasic, Calcium hydroxyphosphate, HAp, Hydroxylapatite, Tribasic calcium phosphate

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About This Item

Linear Formula:
[Ca5(OH)(PO4)3]x
CAS Number:
12167-74-7
Molecular Weight:
502.31
EC Number:
235-330-6
MDL number:
MFCD00010904
UNSPSC Code:
12352302
PubChem Substance ID:
57648308
NACRES:
NA.23

grade

reagent grade

Quality Level

100

form

powder
solid

mp

1100 °C (lit.)

solubility

H2O: insoluble(lit.)

SMILES string

[Ca++].[Ca++].[Ca++].[Ca++].O[Ca+].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O

InChI

1S/5Ca.3H3O4P.H2O/c;;;;;3*1-5(2,3)4;/h;;;;;3*(H3,1,2,3,4);1H2/q5*+2;;;;/p-10

InChI key

XYJRXVWERLGGKC-UHFFFAOYSA-D

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General description

Hydroxyapatite is a key inorganic phosphate that has chemical and structural resemblance to bone. HAp is a popular biomaterial which finds use as a bone or teeth replacement and repair, hard tissue repair.

Application

Hydroxyapatite(HAp) was used to model intracranial calcification in a study. HAp forms biocomposites with a number of polymers for various uses, such as:
  • for comparison purposes during the preparation of HAp based biocomposites with PVA and collagen.
  • for preparation of poly(methyl methacrylate) (PMMA)/hydroxyapatite (HA) by powder liquid method to manufacture denture base composites.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Biocomposites of nanohydroxyapatite with collagen and poly (vinyl alcohol).
Degirmenbasi N, et al.
Colloids and Surfaces. B, Biointerfaces, 48(1), 42-49 (2006)
Differentiation of low-attenuation intracranial hemorrhage and calcification using dual-energy computed tomography in a phantom system.
Nute JL, et al.
Investigative Radiology, 50(1), 9-9 (2015)
Effects of titanate coupling agent on the mechanical, thermal, and morphological properties of poly (methyl methacrylate)/hydroxyapatite denture base composites.
Tham WL, et al.
Journal of Composite Materials, 45(22), 2335-2345 (2011)
Hydroxyapatite and hydroxyapatite-based ceramics.
Orlovskii VP, et al.
Inorganic Materials, 38(10), 973-984 (2002)
Simulated body fluid and water absorption effects on poly (methyl methacrylate)/hydroxyapatite denture base composites.
Tham WL, et al.
Express Polymer Letters, 4(9), 517-528 (2010)
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