Iron oxide nanoparticles for magnetically-guided and magnetically-responsive drug delivery.

Iron oxide nanoparticles for magnetically-guided and magnetically-responsive drug delivery.

International journal of molecular sciences (2015-04-14)

Joan Estelrich, Elvira Escribano, Josep Queralt, Maria Antònia Busquets

RESUMEN

In this review, we discuss the recent advances in and problems with the use of magnetically-guided and magnetically-responsive nanoparticles in drug delivery and magnetofection. In magnetically-guided nanoparticles, a constant external magnetic field is used to transport magnetic nanoparticles loaded with drugs to a specific site within the body or to increase the transfection capacity. Magnetofection is the delivery of nucleic acids under the influence of a magnetic field acting on nucleic acid vectors that are associated with magnetic nanoparticles. In magnetically-responsive nanoparticles, magnetic nanoparticles are encapsulated or embedded in a larger colloidal structure that carries a drug. In this last case, an alternating magnetic field can modify the structure of the colloid, thereby providing spatial and temporal control over drug release.

MATERIALES

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900062

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Iron oxide (II,III), nanoparticles, 30 nm avg. part. size (TEM), 5 mg/mL in H₂O

900026

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Iron oxide (II,III), nanoparticles, 15 nm avg. part. size (TEM), PEG functionalized, 1 mg/mL in H₂O

900042

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Iron oxide (II,III), nanoparticles, 25 nm avg. part. size (TEM), 5 mg/mL in H₂O

900043

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Iron oxide (II,III), nanoparticles, 15 nm avg. part. size (TEM), 5 mg/mL in H₂O

900034

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Iron oxide (II,III), nanopowder, 25 nm, NHS ester functionalized

900082

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Iron oxide (II,III), nanoparticles, 5 nm avg. part. size (TEM), 5 mg/mL in chloroform

900091

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Iron oxide (II,III), nanoparticles, 10 nm avg. part. size (TEM), streptavidin functionalized, 1 mg/mL in H₂O

900148

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Iron oxide (II,III), nanoparticles, 30 nm avg. part. size (TEM), streptavidin functionalized, 1 mg/mL in H₂O

900084

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Iron oxide (II,III), nanoparticles, 10 nm avg. part. size (TEM), 5 mg/mL in chloroform

900064

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Iron oxide (II,III), nanoparticles, 25 nm avg. part. size (TEM), 5 mg/mL in toluene

900200

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Iron oxide (II,III), nanoparticles, 15 nm avg. part. size (TEM), carboxylic acid functionalized, 5 mg/mL in H₂O

900088

Sigma-Aldrich

Iron oxide (II,III), nanoparticles, 20 nm avg. part. size (TEM), 5 mg/mL in chloroform

900092

Sigma-Aldrich

Iron oxide (II,III), nanoparticles, 15 nm avg. part. size (TEM), streptavidin functionalized, 1 mg/mL in H₂O