Saltar al contenido
Merck

Synthesis of Chiral α-Amino Tertiary Boronic Esters by Enantioselective Hydroboration of α-Arylenamides.

Journal of the American Chemical Society (2015-05-06)
Naifu Hu, Guoqing Zhao, Yuanyuan Zhang, Xiangqian Liu, Guangyu Li, Wenjun Tang
RESUMEN

The rhodium-catalyzed asymmetric hydroboration of α-arylenamides with BI-DIME as the chiral ligand and (Bpin)2 as the reagent yields for the first time a series of α-amino tertiary boronic esters in good yields and excellent enantioselectivities (up to 99% ee).

MATERIALES
Referencia del producto
Marca
Descripción del producto

Sigma-Aldrich
(S)-BIDIME, ≥97%
Sigma-Aldrich
(R)-BIDIME, ≥97%
Sigma-Aldrich
(R)-AntPhos, ≥97%
Sigma-Aldrich
(S)-AntPhos, ≥97%
Sigma-Aldrich
(2R,3R)-iPr-BIDIME