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Drug release from electric-field-responsive nanoparticles.

ACS nano (2011-11-25)
Jun Ge, Evgenios Neofytou, Thomas J Cahill, Ramin E Beygui, Richard N Zare
RESUMEN

We describe a new temperature and electric field dual-stimulus responsive nanoparticle system for programmed drug delivery. Nanoparticles of a conducting polymer (polypyrrole) are loaded with therapeutic pharmaceuticals and are subcutaneously localized in vivo with the assistance of a temperature-sensitive hydrogel (PLGA-PEG-PLGA). We have shown that drug release from the conductive nanoparticles is controlled by the application of a weak, external DC electric field. This approach represents a novel interactive drug delivery system that can show an externally tailored release profile with an excellent spatial, temporal, and dosage control.

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Sigma-Aldrich
Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide), average Mn (1,600-1,500-1,600), lactide:glycolide 75:25
Sigma-Aldrich
Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide), average Mn (1,700-1,500-1,700), lactide:glycolide (95:5)